Aminooxy-PEG7-NHBoc

Product Information

Description	Aminooxy-PEG7-NH-Boc is an Aminooxy PEG Linker. Aminooxy-PEG can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. PEG Linkers may be useful in the development of antibody-drug conjugates and drug delivery methods.
Synonyms	Aminooxy-PEG7-C2-NH-Boc; tert-butyl (23-(aminooxy)-3,6,9,12,15,18,21-heptaoxatricosyl)carbamate
IUPAC Name	tert-butyl N-[2-[2-[2-[2-[2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate
SMILES	O=C(OC(C)(C)C)NCCOCCOCCOCCOCCOCCOCCOCCON
InChI	InChI=1S/C21H44N2O10/c1-21(2,3)33-20(24)23-4-5-25-6-7-26-8-9-27-10-11-28-12-13-29-14-15-30-16-17-31-18-19-32-22/h4-19,22H2,1-3H3,(H,23,24)
InChIKey	GRWGCFZSPJVFKG-UHFFFAOYSA-N
Purity	≥95%
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

Aminooxy-PEG7-NHBoc, a versatile chemical reagent, finds extensive applications in bioconjugation and drug development endeavors. Here are four key applications presented with high perplexity and burstiness:

Bioconjugation: Aminooxy-PEG7-NHBoc plays a pivotal role in bioconjugation strategies, facilitating the linkage of biomolecules like proteins, peptides, or nucleic acids with diverse functional entities. The inclusion of the flexible PEG7 spacer ensures optimal solubility and flexibility, allowing the conjugated biomolecules to retain their biological activity. This capability is crucial in the development of targeted therapies and diagnostic tools, demanding precise molecule attachment.

Drug Delivery Systems: Delving into the realm of drug delivery systems, Aminooxy-PEG7-NHBoc emerges as a key player in designing advanced delivery mechanisms. By conjugating drugs to the aminooxy group, targeted delivery to specific tissues or cells can be precisely achieved, effectively minimizing side effects and enhancing therapeutic efficacy. The strategic incorporation of the PEG spacer further contributes to improving solubility and stability of the drug conjugate within biological milieus.

Surface Modification: Within the domain of biomedical research, Aminooxy-PEG7-NHBoc finds utility in the modification of biomaterial surfaces with bioactive molecules, elevating biocompatibility and functionality of implants, sensors, and medical devices. The introduction of the PEG linker works to mitigate protein adsorption and cell adhesion, thereby reducing the risk of immune reactions and enhancing overall biocompatibility.

Proteomics: In the intricate realm of proteomic studies, Aminooxy-PEG7-NHBoc serves as a valuable tool for labeling and analyzing proteins. Through its interaction with carbonyl groups on oxidized glycoproteins, this reagent facilitates the detection and quantification of specific proteins within complex biological samples. This analytical capability empowers researchers to delve deeper into protein function, post-translational modifications, and detailed protein-protein interactions, shedding light on the intricate world of proteomics.

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