Liposome Preparation Services

Liposome Preparation Support Services at BOC Sciences

BOC Sciences possesses a professional liposome preparation platform and an experienced technical team, providing full-process liposome preparation support from laboratory R&D to industrial scale-up. We support the preparation of various types of liposomes to meet the needs of drug delivery, gene transfer, cosmetics, and functional foods, ensuring high encapsulation efficiency, controllable particle size, and stability. Customized liposome design and optimization solutions can also be tailored according to client-specific requirements.

Single-Layer Liposomes

• Provides uniform particle size control to ensure stable and predictable delivery of drugs or active molecules in vivo.
• Supports large-scale production, guaranteeing batch-to-batch consistency.
• Membrane composition can be optimized based on the properties of active ingredients to achieve high encapsulation efficiency.

Multilayer Liposomes

• Supports multilayer membrane design to achieve sustained and prolonged release of active substances.
• The number of layers and particle size can be adjusted by controlling lipid ratios and hydration conditions.
• Provides high encapsulation capacity, suitable for macromolecular drugs or high-load requirements.

Functionalized Liposomes

• Responsive functional molecules (e.g., pH-sensitive, temperature-sensitive) can be incorporated into the membrane as needed.
• Supports surface modification to achieve targeted or controlled-release functions.
• Offers multi-functional carrier designs to enhance delivery efficiency and stability.

Targeted Liposomes

• Can be modified with antibodies, ligands, or carbohydrates for precise targeting of specific tissues or cells.
• Supports targeted delivery of drugs and active molecules to improve efficacy and reduce side effects.
• Provides design optimization for targeted liposomes, ensuring stable surface modification and biocompatibility.

Gene/Nucleic Acid Delivery Liposomes

• Supports encapsulation of DNA, mRNA, siRNA, and other nucleic acids, protecting them from degradation.
• Lipid membrane composition can be optimized to improve cellular uptake and transfection efficiency.
• Offers in vitro and in vivo delivery validation support to ensure effective carrier functionality.

Nano/Micron Liposomes

• Particle size can be adjusted from nanometer to micrometer range to meet diverse application scenarios.
• Provides uniform distribution control to enhance circulation stability and delivery performance.
• Supports industrial-scale preparation with consistent batch quality.

PEGylated Liposomes

• Surface modification with polyethylene glycol (PEG) extends circulation time and reduces immune clearance.
• Enables long-acting drug delivery and optimized targeted therapy.
• Supports custom design of PEG chain length and density.

Cosmetic-Grade Liposomes

• Supports encapsulation of active ingredients such as vitamins, antioxidants, and whitening agents.
• Improves skin penetration and enhances cosmetic efficacy.
• Offers stability optimization to extend product shelf life.

Food-Grade Liposomes

• Supports encapsulation of lipid-soluble nutrients, such as vitamins D, E, and ω-3 fatty acids.
• Enhances bioavailability and absorption.
• Complies with food safety standards, suitable for functional foods and nutritional supplements.

Liposome Synthesis & Formulation Development Technology

BOC Sciences provides professional liposome synthesis and formulation development services, leveraging advanced technology platforms and an experienced R&D team to support the full process from formulation design and process optimization to production and characterization. Our technologies improve liposome encapsulation efficiency, particle size uniformity, and stability, providing reliable liposome solutions for drug delivery, gene therapy, cosmetics, and functional foods.

Liposome Formulation Development

• Offers customized liposome formulation design for small molecules, macromolecular proteins, and nucleic acids to optimize encapsulation efficiency and stability.
• Adjusts phospholipid composition, membrane ratio, and surface functionalization to achieve controlled release and targeted delivery.
• Supports optimization for both nano- and micro-liposomes to meet different application needs.
• Systematically validates formulations, including drug loading, release characteristics, and storage stability, ensuring high-quality liposomes.

Liposome Preparation Techniques

• Provides various liposome preparation methods, including thin-film hydration, reverse-phase evaporation, ethanol injection, microemulsion, and high-pressure homogenization.
• Selects the most suitable technique based on client needs to ensure controllable particle size and uniform distribution.
• Supports laboratory preparation, process development, and pilot-scale upscaling for reproducible production.
• Enables functionalized liposome preparation, including PEGylation, targeted modification, and responsive liposome development.

Liposome Production Support

• Offers liposome production from laboratory scale to industrial scale to meet R&D and commercialization requirements.
• Ensures consistency in particle size, encapsulation efficiency, and membrane structure during production.
• Customizable batch sizes support large-scale production of nano- and micro-liposomes.
• Produced under cGMP or laboratory standards to guarantee stable and reliable quality.

Liposome Characterization Services

• Provides analysis of particle size, size distribution, and polydispersity index (PDI) to ensure uniformity.
• Zeta potential measurement evaluates surface charge and suspension stability.
• Encapsulation efficiency and active substance loading are measured via HPLC, UV/fluorescence, etc.
• Membrane structure and morphology characterization using TEM, SEM, and AFM ensures structural integrity and functional control.

Reliable Liposome Solutions Backed by Expertise

• Advanced Liposome Preparation Technologies: Multiple methods including thin-film hydration, reverse-phase evaporation, ethanol injection, and high-pressure homogenization. Optimized for different drugs and active molecules to achieve high encapsulation efficiency and uniform particle size.
• Custom Formulation Development: Personalized liposome formulations designed based on client needs and molecular properties, optimizing membrane composition, encapsulation efficiency, and release performance for nano- and micro-liposomes.
• High Encapsulation Efficiency: Optimized membrane composition, phospholipid ratios, and preparation conditions ensure effective encapsulation of drugs or active molecules while maintaining stability and bioactivity.
• Controllable Particle Size and Uniform Distribution: Ultrasound, extrusion, or high-pressure homogenization precisely control particle size and distribution, improving circulation stability and delivery efficiency.
• Full-Process Production and Scale-Up: Supports laboratory, pilot, and industrial-scale production, ensuring consistent particle size, encapsulation efficiency, and membrane structure for R&D and commercialization.
• Professional Characterization and Analysis: Equipped with DLS, NTA, Zeta potential, HPLC, TEM, SEM, and AFM platforms to ensure controllable and verifiable particle size, encapsulation efficiency, morphology, and membrane integrity.
• Functionalization and Targeting: Supports PEGylation, ligand modification, and responsive functional liposomes, providing controlled release, extended circulation, and tissue-targeting capabilities.
• High-Quality Standards and Strict Control: cGMP or laboratory-grade management ensures uniform particle size, high encapsulation rate, and stable quality.
• Professional Customer Support: Technical consulting, solution design, experimental guidance, and data analysis assist clients in addressing R&D and production challenges for efficient translation.

How Our Liposome Services Work?

BOC Sciences provides professional and systematic liposome preparation and development services, covering the full process from initial consultation to final delivery. By combining advanced technology platforms with extensive experience, we offer clients efficient, controllable and customized liposome solutions.

Requirement Communication & Proposal Evaluation

• Engage in in-depth discussions with clients to understand project goals and application scenarios, analyzing the properties of active molecules and preparation requirements.
• Develop preliminary liposome preparation and formulation development plans to ensure scientific feasibility.

Liposome Design & Formulation Development

• Optimize lipid membrane composition, phospholipid ratios, and functional modifications based on molecular characteristics and application objectives.
• Provide customized formulations with high encapsulation efficiency, controllable particle size, and excellent stability.

Liposome Preparation & Process Optimization

• Prepare liposomes using thin-film hydration, reverse-phase evaporation, ethanol injection, high-pressure homogenization, and other methods.
• Optimize process parameters to ensure uniform particle size, stable distribution, and functionalized liposome performance.

Characterization & Performance Validation

• Perform comprehensive liposome characterization through particle size, PDI, Zeta potential, encapsulation efficiency, and membrane structure analysis.
• Validate preparation quality and functional properties to ensure the product meets expected objectives.

Custom Production & Scale-Up

• Provide liposome production services at laboratory, pilot, and industrial scales to meet needs at different stages.
• Ensure batch consistency, intact membrane structure, and stable drug loading.

Technical Reporting & Customer Support

• Deliver detailed technical reports, including formulations, preparation processes, characterization results, and optimization recommendations.
• Offer continuous technical support to help clients smoothly advance their R&D or commercialization efforts.

Practical Applications of Liposomes for Your Needs

With their unique amphiphilic structure and high biocompatibility, liposomes have wide applications in pharmaceuticals, gene therapy, cosmetics, and nutrition. BOC Sciences provides professional liposome preparation services to help clients achieve efficient delivery and stable release of drugs or active molecules across different applications.

Drug Delivery

• Encapsulate hydrophilic or lipophilic drugs to improve solubility and bioavailability in the body.
• Support controlled-release designs to extend circulation time in vivo.
• Enable targeted drug delivery to reduce side effects on healthy tissues and improve therapeutic efficacy.

Gene & Nucleic Acid Delivery

• Protect nucleic acids such as DNA, RNA, and siRNA from degradation.
• Enhance cellular uptake and transfection efficiency, supporting gene therapy and vaccine development.
• Design functionalized liposomes for targeted delivery to specific tissues or cells.

Cosmetics & Skincare

• Encapsulate vitamins, antioxidants, whitening, or moisturizing ingredients to enhance skin penetration.
• Improve stability of active components and extend product shelf life.
• Support functionalized liposome designs to enhance skincare and cosmetic effects.

Functional Foods & Nutritional Supplements

• Encapsulate lipid-soluble nutrients, such as vitamins D, E, and ω-3 fatty acids, to improve bioavailability.
• Provide safe and stable food-grade liposome carriers.
• Suitable for functional foods and nutritional supplements, enhancing absorption and utilization in the body.

Frequently Asked Questions

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• What is liposomal?

  Liposomes are ultramicrospherical particles with a bilayer structure formed by self-aggregation in water using phospholipids as wall material. The hydrophilic heads of the phospholipids form the inner and outer surfaces of the bilayer, and the lipophilic tail fatty acid chains form the hydrophobic core region of the bilayer. The size of liposomes ranges from 20 nm to several microns, and they may be composed of one or several concentric or non-concentric membranes, each with a thickness of about 4 nm. According to the size of liposomes and the number of lipid bilayers, liposomes can be divided into single-chamber liposomes and multi-chamber liposomes. Among them, single-chamber liposomes can be divided into small single-chamber liposomes (SUV, 20-100 nm), large single-chamber liposomes (LUV, >100 nm) and giant single-chamber liposomes (GUV, >100 nm); multicompartment liposomes can be divided into multicompartment liposomes (MLV, >500 nm) and multivesicular liposomes (MVV, >1000 nm).

• What is liposomal glutathione?

  Liposomal glutathione is a form of the antioxidant glutathione encapsulated within liposomes—tiny lipid-based vesicles. This encapsulation protects glutathione from degradation in the digestive system, improving its absorption and bioavailability compared to standard oral supplements. It is commonly used to support cellular detoxification, enhance immune function, and reduce oxidative stress, making it a more effective option for maintaining overall health and wellness.

• What is liposomal vitamin C?

  Liposomal vitamin C is a form of vitamin C encapsulated in liposomes, which are microscopic fat-based spheres. This delivery method protects vitamin C from stomach acid and digestive breakdown, allowing higher absorption and better bioavailability. It supports immune health, collagen production, and antioxidant defense more effectively than traditional vitamin C supplements. Liposomal vitamin C is often used to enhance overall health, particularly during times of increased oxidative stress.

• What is liposomal delivery?

  Liposomal delivery is a method of transporting nutrients, drugs, or bioactive compounds using liposomes—tiny, spherical vesicles made of phospholipid bilayers. These vesicles can encapsulate both water- and fat-soluble substances, protecting them from degradation in the digestive system and improving absorption. Liposomal delivery enhances bioavailability, ensures targeted delivery to cells or tissues, and is commonly used for vitamins, antioxidants, and pharmaceuticals to maximize effectiveness.

• What types of liposomes can you prepare?

  BOC Sciences can prepare a wide range of liposomes, including unilamellar, multilamellar, PEGylated, targeted, functionalized, nanosized, and micron-sized liposomes. We also support liposomes for gene or nucleic acid delivery, cosmetic formulations, and food-grade applications. Each type is customizable in terms of size, lipid composition, surface modification, and encapsulation properties to meet specific research and industrial requirements.

• What methods are used for liposome preparation?

  We employ multiple preparation techniques, including thin-film hydration, reverse-phase evaporation, ethanol injection, microemulsion, and high-pressure homogenization. These methods allow precise control of liposome size, lamellarity, and encapsulation efficiency. Our experts select the most suitable method based on the payload, desired application, and scale, ensuring optimal performance and reproducibility of the final liposome products.

• Can liposomes be customized for targeted delivery?

  Yes, BOC Sciences can design functionalized and targeted liposomes by modifying their surface with PEG, ligands, or antibodies. These modifications enhance circulation time, reduce immune clearance, and enable tissue or cell-specific delivery. Our team optimizes the lipid composition and surface chemistry to ensure stable, high-efficiency targeted liposomes suitable for drug delivery, gene therapy, or precision medicine research.

• How is liposome quality and stability ensured?

  We perform comprehensive characterization of liposomes, including particle size, polydispersity index (PDI), Zeta potential, encapsulation efficiency, and structural analysis using TEM, SEM, or AFM. Stability assessments under storage or transport conditions are also conducted. These measures ensure reproducible liposome formulations with consistent performance, making them suitable for research, preclinical, and industrial applications.

• What scales of liposome production are supported?

  BOC Sciences provides liposome preparation services at laboratory, pilot, and industrial scales. We ensure batch-to-batch consistency for size, encapsulation efficiency, and lipid composition. Our scalable production capabilities allow clients to transition from small-scale research studies to larger preclinical or commercial production, while maintaining quality, reproducibility, and functional performance.

Case Studies and Success Stories

Publications

Articles published by clients in high-impact journals demonstrate the reliability and scientific value of BOC Sciences' products.

• Liquid chromatography–tandem mass spectrometry method for the analysis of N-(3-aminopropyl)-N-dodecylpropane-1, 3-diamine, a biocidal disinfectant, in dairy products. Food chemistry 262 (2018): 168-177. DOI: 10.1016/j.foodchem.2018.04.080.
• The long-chain monounsaturated cetoleic acid improves the efficiency of the n-3 fatty acid metabolic pathway in Atlantic salmon and human HepG2 cells. Br J Nutr. 2019; 122(7): 755-768. DOI: 10.1017/S0007114519001478.
• Development and validation of rapid and simultaneous method for determination of 12 hair-growth compounds in adulterated products by UHPLC–MS/MS. Forensic science international 284 (2018): 129-135. PMID: 29408720 DOI: 10.1016/j.forsciint.2017.12.042.
• Effect of long-term dietary sphingomyelin supplementation on atherosclerosis in mice. PloS one 12.12 (2017): e0189523. PMID: 29240800 DOI: 10.1371/journal.pone.0189523.
• Osteogenic effects of rapamycin on bone marrow mesenchymal stem cells via inducing autophagy. Journal of Orthopaedic Surgery and Research 18.1 (2023): 129. PMID: 36814286 DOI: 10.1186/s13018-023-03616-9.

Client Testimonials

Industry Distribution of Custom Liposome Synthesis Clients

"We needed highly uniform liposomes for a preclinical drug delivery study. BOC Sciences provided precise formulations with excellent encapsulation efficiency. Their technical support and timely communication exceeded our expectations."

— Dr. Michael Evans, Senior Research Scientist (United Kingdom)

"BOC Sciences helped us develop PEGylated and targeted liposomes for RNA delivery. The quality and reproducibility of their liposomes were outstanding, and the team guided us throughout the process."

— Prof. Laura Schmidt, Molecular Biologist (Germany)

"Our lab required multi-layer liposomes for sustained release experiments. BOC Sciences delivered consistent particle size and stability, enabling us to advance our research without delays."

— Dr. David Miller, Pharmaceutical Scientist (United States)

"Facing challenges in encapsulating sensitive nucleic acids, BOC Sciences provided custom liposome solutions with high RNA stability. Their expertise and support were invaluable."

— Dr. Emma Johnson, Gene Therapy Researcher (Canada)

"We collaborated with BOC Sciences for cosmetic-grade liposome formulations. The liposomes showed excellent skin penetration and long-term stability, greatly enhancing our R&D projects."

— Ms. Sophie Dubois, Cosmetic Formulation Specialist (France)