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NH2-PEG-COOtBu

NH2-PEG-COOtBu has an amine group and a tert-butyl-protected carboxylic acid at each end of the molecular chain and is a linear heterofunctional PEG reagent. It is a useful cross-linking reagent with PEG spacer. The protected carboxyl (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions and it can be regenerated by mild acidic or basic conditions. NH2-PEG-COOtBu is usually sold in its hydrochloric acid or TFA salt form. NH2-PEG-COOtBu is used in cell culture, drug research, drug delivery and release, nanotechnology and new materials. It can also be attached to different molecules or materials to extend the richness of different molecular combinations. PEG modification can form a spatial barrier around the drug, reduce enzymatic hydrolysis of the drug, avoid rapid elimination of kidney metabolism, and allow the drug to be recognized by immune system cells.

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