PEGylation Services

Custom PEGylation Services

In order to accomplish PEGylation, a variety of chemical modifications are utilized to prepare an active PEG derivative with a reactive functional group at one or both termini. Further the use of reactive functional group mainly depends on the substrate to be conjugated to PEG. Our PEGylation techniques can be roughly divided into the following parts:

• PEGylated Peptides and Proteins

  Among the 20 types of common amino acids that make up proteins, only those with polar side chain groups can be chemically modified. The activated PEG realizes the coupling through chemical reaction with the amino acid residues on the peptide or protein molecules. The active groups on these amino acid residues are mostly nucleophilic, and their activity usually decreases in the following order: sulfhydryl > α-amino > ɛ-amino > carboxy > hydroxyl. With our expertise as a leader in the field of PEGylation, BOC Sciences can offer you great services to help you design desired PEGylated proteins

• PEGylated Nanoparticles

  The addition of PEG to the nanocarrier surface can reduce many of challenges, such as reducing reticuloendothelial system (RES) uptake and increasing circulation time versus uncoated counterparts. Due to difference in the chemical make-up, strategies used for PEGylation of nanocarriers can be broadly classified under the titles of polymeric nanoparticles, liposomes, micelles and inorganic nanoparticles. Our expertise in polymer chemistry and surface science can provide you practice advices, help you design the experiment, and prepare PEG functionalized products for your needs.

• PEGylated Drugs

  To date, many organic small molecule drugs have gradually adopted PEGylation technology and certain progress has been made. The conjugated drugs also has good biocompatibility, can be dissolved in the tissue fluid in the body, and can be quickly excreted from the body without any toxic side effects. Pease contact us for more details of our preclinical PEGylation service. BOC Sciences's dedicated and experienced PEGylation group will offer you the most optimal solution for your project.

• PEGylated Lipid

  PEGylation of lipids is an effective strategy to improve the pharmacokinetic properties of lipid drugs. By attaching PEG chains to lipids, researchers can enhance the solubility, stability, and circulation time of lipid drug formulations , thereby improving bioavailability and therapeutic efficacy. Additionally, PEGylation can help reduce the immunogenicity and toxicity of lipid drugs, making them safer to use in patients. BOC Sciences can provide PEGylation services for a variety of lipid molecules , including phospholipids , cholesterol , and glycolipids.

• PEGylated Amino Acids

  PEGylation of amino acids involves attaching PEG to the side chains of amino acids, which can improve the pharmacokinetic properties of biomolecules. PEGylation of amino acids can also reduce immunogenicity and increase the circulating half-life of peptides and proteins. BOC Sciences offers custom PEGylation services of amino acids with precise control over the degree of PEGylation and the size of the attached PEG chain.

• PEGylated Antibody

  PEGylation of antibodies is a widely used strategy to improve the pharmacokinetic properties and stability of therapeutic antibodies. BOC Sciences offers PEGylated antibodies and antibody fragment services, providing customized solutions to improve antibody stability, half-life and efficacy. We offer comprehensive services including PEGylation optimization, conjugation chemistry, analytical method development and quality control.

• PEGylated Carbohydrates

  Carbohydrates are important biomolecules that play key roles in many biological processes and have multiple potential applications in the development of new drugs and therapies. PEGylation of carbohydrates can improve the pharmacokinetic properties and solubility of carbohydrate-based drugs and diagnostics. BOC Sciences can provide PEGylation services for a variety of carbohydrate molecules, including monosaccharides, oligosaccharides, and polysaccharides.

• PEGylated Biotin

  Biotin is a vitamin, also known as vitamin H, that is an important component of biotechnology and biomedical research. PEGylation of biotin involves conjugating PEG chains to biotin molecules and can be achieved using PEGs of different molecular weights and structures. BOC Sciences can provide customized biotin PEGylation services based on customer specific requirements.

• PEGylated Nucleic Acids

  PEGylation of nucleic acids can improve their stability, pharmacokinetics, and biodistribution, as well as reduce immunogenicity and improve their cellular uptake, making them more suitable for therapeutic applications. BOC Sciences offers a wide range of nucleic acid PEGylation services, including PEGylation of RNA, DNA, siRNA, oligonucleotides, and other nucleic acid derivatives. We can perform PEGylation at various locations on nucleic acid molecules, including the 5’ and 3’ ends, internal sites, and specific functional groups.

• PEGylated Enzymes

  PEGylation of enzymes is a practical approach to improve the stability, solubility, and pharmacokinetic properties of enzyme-based therapeutics and diagnostics. BOC Sciences offers custom PEGylation services for enzymes, allowing for the attachment of PEG chains to enzyme molecules. PEGylation of enzymes can enhance their stability under harsh conditions, increase their solubility, and extend their circulating half-life. We can provide PEGylation services for a variety of enzymes, including proteases, lipases, and polymerases.

• PEGylated Cytokines

  Cytokines are signaling proteins that regulate immune responses in the body, and when PEGylated, they can have longer half-lives and reduced toxicity, leading to more effective treatments. BOC Sciences offers PEGylation services for a variety of cytokines, including interleukins, interferons, and growth factors. Our PEGylation services are performed in state-of-the-art facilities using strict quality control measures to ensure the highest standards of product quality and consistency.

• PEGylated Oligonucleotides

  PEGylation of oligonucleotides involves attaching polyethylene glycol (PEG) molecules to oligonucleotide chains, enhancing their stability, solubility, and bioavailability. This modification reduces nuclease degradation, prolongs circulation time, and improves tissue targeting. PEGylated oligonucleotides are widely used in drug delivery systems, gene therapies, and antisense oligonucleotide-based treatments, optimizing therapeutic efficacy and minimizing immune responses.

PEGylation Service Process

• Tell Us Your Request

  What's your further application & special requirement.

• We Provide the Optimized Scheme

  Screening of PEGylation reagents & biological activities & reaction conditions.

• Contract & Send Samples

  Contract & pay deposit, which will be refund if the PEGylation services unfinished.

• One-Stop PEGylation Service

  Our dedicated R&D team can help you obtain the right high quality PEGylated products for your need.

• Deliver Samples with Detailed Reports

  Pay the balance and we will deliver the samples with detailed reports.

Frequently Asked Questions

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• What is the Process of PEGylation?

  The PEGylation process involves chemically attaching polyethylene glycol (PEG) molecules to target molecules such as proteins, drugs, or antibodies. Common PEGylation methods include reacting precursor molecules with reactive PEG functional groups (e.g., amino or carboxyl groups) to form covalent bonds. The typical steps include selecting appropriate PEG molecules, often functionalized PEG with reactive groups, and then reacting them with the target molecule to complete PEGylation. This process can be carried out using solution-based methods, solid-phase methods, or enzyme-catalyzed reactions. Successful PEGylation significantly improves the solubility, stability, and bioavailability of target molecules while extending their half-life in the body.

• What is PEGylated Interferon?

  PEGylated interferon refers to interferon modified with PEG, commonly used to treat chronic hepatitis B and C. Interferon is a natural protein that enhances immune responses and inhibits viral replication. PEGylation attaches PEG molecules to interferon, extending its half-life in the body and slowing its metabolic rate. This reduces the frequency of injections and improves patient adherence to treatment. Compared to non-PEGylated interferon, PEGylated interferon generally has longer-lasting therapeutic effects and fewer side effects.

• How Does PEGylated Interferon Work?

  PEGylated interferon works by enhancing the body's immune response and directly inhibiting viral replication to treat viral infections. The PEGylation of interferon molecules increases their size and hydrophilicity, allowing for longer circulation time in the body and reducing their clearance rate. This decreases the frequency of administration while improving convenience and therapeutic effectiveness. The mechanism involves activating immune system cytokines to enhance antiviral activity, while interferon itself directly interferes with viral replication. The application of PEGylation technology has significantly improved the efficacy of PEGylated interferon, especially in long-term treatments.

• What is PEGylated Liposomal Doxorubicin?

  PEGylated liposomal doxorubicin is a cancer drug where doxorubicin is encapsulated in liposomes and further modified with PEG on the liposome surface. Through PEGylation, the liposomes enhance the pharmacokinetic properties of doxorubicin, allowing it to stay in the bloodstream longer, reduce toxicity to healthy tissues, and improve targeting of cancer cells. PEGylated liposomal doxorubicin is widely used to treat various cancers, such as breast cancer, ovarian cancer, and non-Hodgkin's lymphoma, effectively reducing the side effects commonly associated with traditional doxorubicin therapies.

• What does PEGylated mean?

  The PEGylation process involves covalently attaching PEG molecules to drugs or therapeutic proteins through chemical bonding. PEG is a hydrophilic, biocompatible, and non-toxic polymer that has been extensively studied and approved by regulatory agencies for drug delivery applications. PEGylation can effectively reduce the immune response to drugs in the body, enhance bioavailability, and extend circulation time, thereby reducing rapid clearance. This modification is widely applied in biopharmaceuticals, such as antibody-drug conjugates, vaccines, and enzyme replacement therapies. Additionally, PEG possesses biocompatibility and non-toxicity, and by adjusting the molecular weight and linkage methods of PEG, the drug characteristics of PEGylated molecules can be flexibly modulated to achieve optimal therapeutic effects and patient tolerance.

• What are the advantages of PEGylation?

  One of the key advantages of PEGylation technology is the ability to prolong the circulation time of drugs in the body. PEG molecules form a protective barrier around drug molecules, preventing them from being quickly cleared by the immune system or enzymatically degraded. The extended circulation time allows the drug to reach its target tissue more efficiently and exert its therapeutic effect over a longer period of time. Additionally, PEGylation can reduce the immunogenicity of certain drugs by protecting them from recognition by the immune system. Examples include therapeutic proteins and antibodies, which may induce immune responses in some patients. By pegylating these drugs, researchers can minimize their immunogenic potential and improve their safety and tolerability in patients. By attaching PEG molecules to drug delivery systems such as liposomes or nanoparticles, researchers can extend their circulation time in the body, increase their tissue permeability, and increase their accumulation at specific target sites.

• What support can BOC Sciences provide for PEG and PEGylation?

  At BOC Sciences, we offer a variety of PEGylation reagents to help researchers and organizations improve the performance of their products. Our PEGylation services come in a variety of formats, including off-the-shelf reagents, custom PEGylation and manufacturing services. Our PEGylation reagents are designed to be multifunctional, efficient and easy to use, including PEG chains of different lengths and chemical linkers that can modify various molecules quickly and effectively. For researchers with more specialized needs, we also offer custom PEGylation services, where our team of experts can design and optimize PEGylation strategies based on their specific molecules.