Lipidomics is an important branch of systems biology, focusing on the qualitative, quantitative, and functional analysis of all lipid molecules within a biological system. Lipidomics analysis refers to the systematic study of lipid species, structures, abundances, and their dynamic changes in cells, tissues, body fluids, or other biological samples using high-throughput analytical technologies. As a specialized independent provider of lipid compounds and custom analytical services, BOC Sciences leverages an experienced team of biochemistry and analytical chemistry experts along with advanced lipidomics platforms to deliver high-quality and reliable lipidomics analysis services to clients worldwide. Our service offerings include non-targeted lipidomics, targeted lipidomics, and semi-targeted lipidomics. We analyze a wide range of sample types—including cells, tissues, serum, plasma, urine, and other biological fluids—to meet the diverse needs of research, drug development, and clinical studies.
Comprehensive Lipidomics Analysis Services for Your Research
BOC Sciences' lipidomics analysis services provide comprehensive profiling of lipid molecules in biological samples, including the identification and quantification of diverse lipid species, lipid profiling, pathway analysis, and studies of lipid metabolism. Our services cover a wide range of lipid classes, including, but not limited to, glycerolipids, glycerophospholipids, sphingolipids, and sterol lipids.
Lipid Category
Analytes
Lipid Category
Analytes
Fatty Acyls
Short-, medium-, and very-long-chain fatty acids
Saturated and unsaturated fatty acids
Free fatty acids (FFA)
Branched and straight-chain fatty acids
Total trans-fatty acid quantification
Linoleic acid and α-linolenic acid
Omega-3 and Omega-6 fatty acid profiles
Sphingolipids
Ceramides (Cer)
Sphingomyelins (SM)
Glycosphingolipids (GlcCer, LacCer)
Sphingoid base derivatives
Gangliosides
Hexosylceramides
Glycerophospholipids
Phosphatidylcholine (PC)
Phosphatidylethanolamine (PE)
Phosphatidylserine (PS)
Phosphatidylinositol (PI)
Lysophospholipids
Sterol Lipids
Total cholesterol
Free cholesterol
Cholesteryl esters
Oxysterols
Steroids
Steroid hormones and metabolites
Glycerolipids
Triacylglycerols (TAG)
Diacylglycerols (DAG)
Monoacylglycerols (MAG)
Triacylglycerol derivatives
Fatty acid glycerides
Phospholipid derivatives
Complex Lipids
Dihydroceramides (DCER)
Hexosylceramides (HCER)
Lactosylceramides (LCER)
Lysophosphatidylcholine (LPC)
Lysophosphatidylethanolamine (LPE)
Monoacylglycerols (MAG)
Looking for Lipidomics Analysis Services?
Whether you need non-targeted, targeted, or semi-targeted lipidomics analysis, our experts deliver high-resolution lipid profiling and actionable insights for your research and drug development.
High-Resolution Lipidomics Platform for In-Depth Lipid Analysis
At BOC Sciences, we leverage advanced lipidomics technology platforms and extensive analytical experience to provide high-precision, high-throughput, and customizable lipid analysis solutions. Whether performing comprehensive lipid profiling of complex biological samples or targeted quantification of specific lipid pathways, we utilize liquid chromatography, high-resolution mass spectrometry, and professional data processing capabilities to rapidly generate reliable lipid information, supporting diverse needs in research, drug development, and clinical studies.
Sample Collection and Preparation
BOC Sciences offers standardized and reproducible sample preparation workflows:
Common sample types include cells, tissues (liver, brain, tumor, etc.), serum, plasma, urine, cerebrospinal fluid, microbial, and plant samples.
Cell and tissue samples: frozen grinding, homogenization, and efficient lipid extraction.
Blood and body fluid samples: rapid separation, protein removal, and internal standard addition to ensure quantitative accuracy.
Common lipid extraction methods include Folch, Bligh & Dyer, and MTBE methods, maximizing lipid stability and integrity.
Chromatographic Separation Technologies
BOC Sciences is equipped with multiple chromatography platforms:
Liquid Chromatography (LC)
Reverse-phase LC (RPLC): separates lipids by fatty acid chain length and unsaturation.
Normal-phase LC (NPLC) and HILIC: separates lipids by polarity or headgroup.
Gas Chromatography (GC)
Primarily used for fatty acid methyl ester (FAME) analysis.
Mass Spectrometry Detection Technologies
High-resolution mass spectrometry platforms enable precise lipid characterization:
Orbitrap and Q-TOF platforms allow accurate identification of lipid molecules.
Ionization methods include ESI (electrospray ionization) and APCI (atmospheric pressure chemical ionization).
Tandem mass spectrometry (MS/MS) provides structural information, such as fatty acid position and double-bond location.
Data Processing and Bioinformatics Analysis
Advanced software and algorithms are used to:
Perform peak identification, alignment, and quantification.
Conduct lipid identification and database matching (LIPID MAPS, HMDB, SwissLipids).
Why Choose Our Lipidomics Technology and Services?
Professional Team: Our team consists of biochemistry, analytical chemistry, and bioinformatics experts with over 20 years of lipidomics experience, proficient in multiple mass spectrometry platforms and data analysis methods, ensuring efficient execution of complex projects.
Advanced Instrumentation: Equipped with Orbitrap and Q-TOF high-resolution mass spectrometers and multi-channel LC/GC systems, achieving ppm-level resolution and sub-nanomolar detection, supporting comprehensive lipidomics profiling.
Customizable Solutions: We provide end-to-end tailored solutions based on sample type and research goals, including sample preparation, lipid extraction, chromatographic separation, mass spectrometry detection, and bioinformatics data analysis.
High-Quality Data Assurance: Standardized workflows and internal standards ensure highly accurate qualitative and quantitative lipid data (RSD<10%), providing reliable, reproducible, and cross-experiment comparable results.
Global Service and Rapid Response: Serving research institutions and companies across North America, Europe, Asia, and beyond, offering optimized sample shipping, online consultation, and project tracking with 24–48 hour response.
Flexible Analytical Options: Non-targeted, targeted, and semi-targeted lipidomics analyses are available, detecting thousands of lipid molecules simultaneously and supporting multi-pathway metabolic network analysis to meet diverse research needs.
Technological Innovation and Continuous Optimization: We continuously upgrade mass spectrometry hardware and data processing algorithms, employing high-resolution MS/MS and multidimensional LC techniques to enhance lipid identification depth and structural elucidation, leading cutting-edge lipidomics research.
End-to-End Lipidomics Workflow with Expert Support
At BOC Sciences, we are committed to providing high-precision, end-to-end lipidomics solutions. Leveraging advanced mass spectrometry and chromatography platforms, standardized procedures, and professional data analysis capabilities, we deliver reliable, reproducible, and customizable services from sample preparation to results interpretation, helping researchers and companies deeply analyze lipid metabolic networks to achieve scientific and drug development goals.
Consultation and Needs Assessment
At the project initiation stage, BOC Sciences works closely with clients to understand research objectives, sample types, and expected outcomes, developing a personalized lipidomics analysis plan. This ensures strategies align with scientific goals while maximizing use of our technology platforms, avoiding unnecessary costs and repeated experiments.
Sample Preparation and Shipment
To ensure accurate and reproducible lipid analysis, we provide detailed guidance on sample collection, handling, and shipment. Whether cells, tissues, or blood/body fluid samples, clients are guided on cold storage, rapid separation, and internal standard addition to minimize sample degradation or oxidation.
Lipid Extraction and Separation
Standardized, efficient lipid extraction methods (Folch, Bligh & Dyer, MTBE) are used to preserve lipid integrity. Chromatographic separation via LC or GC allows high-resolution profiling of multiple lipid species in complex samples while maintaining sensitivity and accuracy.
Mass Spectrometry Detection and Data Acquisition
High-resolution mass spectrometry (Orbitrap, Q-TOF) combined with MS/MS analysis captures precise lipid mass and structural information. ESI and APCI ionization techniques provide broad lipid coverage and allow detection of low-abundance lipid molecules for comprehensive lipidomic profiling.
Data Processing and Bioinformatics Analysis
After raw data acquisition, our expert team performs peak identification, alignment, and quantification, matching lipids against databases such as LIPID MAPS and HMDB. Multivariate statistical analyses (PCA, PLS-DA) and metabolic pathway interpretation generate visualized results, enabling clients to quickly understand lipid changes and their biological significance.
Results Reporting and Interpretation
Clients receive a complete analysis report, including lipid identification lists, quantitative data, differential lipid analysis, and metabolic pathway visualization. The report provides detailed biological interpretation to support research publications, drug development decisions, or clinical applications, with expert consultation available to explain complex results.
Interested in Our Custom Lipid Solutions?
Contact our lipid chemistry experts to discuss your project needs.
Lipidomics Applications Across Biomedical and Life Sciences
Lipidomics analysis provides molecular-level, high-resolution information on lipid composition, metabolic networks, and dynamic changes, supporting multidisciplinary research. Whether exploring disease mechanisms, guiding drug development, or evaluating nutritional interventions and environmental adaptation, lipidomics delivers quantifiable lipid data for informed scientific and clinical decision-making.
Disease Mechanism and Biomarker Research
Lipid metabolism abnormalities are closely linked to various diseases, including:
Cancer
Cardiovascular diseases
Diabetes and metabolic syndrome
Neurodegenerative diseases
Inflammatory and immune-related disorders
Lipidomics analysis can reveal disease-associated lipidomic alterations, identify potential biomarkers, and support early diagnosis, disease stratification, and precision therapy development.
Drug Development and Efficacy Evaluation
Lipidomics can be applied to:
Investigate drug mechanisms of action
Analyze drug-induced lipid metabolic changes
Assess drug safety and toxicity
Optimize nano-drug and lipid delivery systems
High-throughput lipidomics quantifies the impact of drugs on hundreds to thousands of lipid species, providing critical data for efficacy evaluation, dose optimization, and novel drug development.
Nutrition and Metabolism Research
Lipidomics can systematically analyze dietary or nutritional intervention effects on lipid profiles, including:
Impact of functional foods on lipid metabolism
Regulation of blood lipids, triglycerides, and phospholipids by dietary interventions
Energy metabolism and fatty acid oxidation pathway analysis
Quantitative lipid and metabolic pathway analysis supports rational nutrition strategies, metabolic health assessment, and functional food development or personalized dietary interventions.
Microbiology and Environmental Research
Lipidomics can be applied to:
Analyze microbial lipid composition and metabolic characteristics
Study lipid metabolism responses to environmental stress (temperature, pH, nutrient deficiency)
Investigate lipid biosynthesis pathways and regulatory mechanisms
Comprehensive analysis of microbial or environmental lipidomes helps researchers understand adaptation mechanisms, metabolic networks, and biosynthetic potential, providing reliable data for microbial engineering, ecology, and environmental monitoring.
Lipidomics analysis can provide in-depth information about the lipid composition of biological samples. Through lipidomics analysis, the differential lipids between samples can be accurately and quantitatively screened, and the relationship between these differences and various biological processes and disease states can be understood.
First, lipidomic analysis can reveal the type and content of lipids. This information can be used to understand the physiological and pathological states of organisms. Because lipids are not only the main components of cell membranes and lipid droplets, they also play an important role in a wide range of biological processes, such as signal transduction, transport, and biological macromolecule sorting. In addition, lipidomics can provide information about the metabolic status of cells. For example, many lipids can also serve as important second messengers or precursor substances to participate in signaling in vivo.
What sample types can you analyze in lipidomics studies?
We accept a wide range of biological samples, including cells, tissues, serum, plasma, urine, and other body fluids. Our standardized sample preparation and storage protocols ensure lipid stability and data reliability. In addition, we provide expert guidance on sample collection and transportation to maintain sample integrity, enabling accurate and reproducible lipidomics analysis for diverse research and drug development applications.
What is the difference between targeted and untargeted lipidomics?
Targeted lipidomics focuses on the quantitative analysis of specific lipid classes or pathways, offering high accuracy and repeatability. Untargeted lipidomics provides a comprehensive profile of all detectable lipids, ideal for discovering novel or differential lipid molecules. We offer both approaches, allowing clients to select the best strategy according to research goals and sample type.
How do you ensure data quality and reproducibility?
We use standardized operating procedures, internal standards, and validated extraction methods to maintain high data quality. High-resolution mass spectrometry and advanced chromatography techniques enable precise lipid identification and quantification. Our experienced bioinformatics team performs rigorous data processing, statistical analysis, and pathway mapping, ensuring results are accurate, reproducible, and suitable for publication or regulatory use.
Can you support custom lipid panels or specialized lipid pathways?
Yes, we offer customized lipidomics solutions tailored to specific research goals. Whether it's a defined lipid panel, rare lipid class, or particular metabolic pathway, our team can design extraction protocols, chromatography methods, and mass spectrometry strategies. This flexibility ensures precise quantification and comprehensive coverage of the lipids most relevant to a study.
How are the lipidomics results delivered?
We provide comprehensive, easy-to-interpret reports, including qualitative and quantitative lipid profiles, statistical analysis, and pathway visualization. Data can be delivered in Excel, PDF, or compatible formats for downstream analysis. Our team also offers expert interpretation and consultation to help clients understand lipid changes and their biological significance, supporting research decisions and publications.
Case Studies and Success Stories
Background
A Canadian biopharmaceutical company is developing novel targeted drugs and aims to use phospholipidomics analysis to reveal how the drugs regulate the lipid composition and metabolic pathways of tumor cell membranes. The research team's goal is to identify potential lipid biomarkers for evaluating drug efficacy and exploring resistance mechanisms, providing a molecular basis for precision therapy. As phospholipids are key components of cell membranes and central signaling molecules, their alterations have significant effects on tumor biological characteristics. Therefore, comprehensive and precise phospholipidomics analysis is essential.
What Does BOC Sciences Do?
BOC Sciences provides end-to-end phospholipidomics analysis services for clients:
Standardized lipid extraction from tumor cell samples using the Folch method to ensure phospholipid integrity.
Qualitative and quantitative analysis of phospholipids, including PC, PE, PS, and PI, using high-resolution liquid chromatography–mass spectrometry (LC-HRMS).
Multivariate statistical analysis (PCA, PLS-DA) and phospholipid metabolic pathway analysis conducted by our expert data analysis team to identify differential lipids and potential biomarkers.
Key Outcomes
Successfully identified and quantified over 500 phospholipid molecules, covering major phospholipid classes such as PC, PE, PS, and PI.
Observed significant changes in specific PC/PE ratios in drug-treated groups, suggesting potential drug regulation of membrane structure and signaling pathways.
Provided visualized metabolic pathway reports, offering direct support for optimizing drug design, evaluating efficacy, and investigating resistance mechanisms.
Background
Patients with diabetes and metabolic syndrome often exhibit lipid metabolism disorders, particularly abnormal levels of fatty acids and their derivatives in serum, which directly affect insulin sensitivity, inflammatory responses, and energy metabolism. A U.S. research institution is investigating how these lipid metabolism abnormalities drive disease progression and aims to discover potential biomarkers associated with disease development through fatty acid and oxidized fatty acid profiling. The research objectives include identifying key lipid molecules, analyzing metabolic pathway alterations, and providing a molecular basis for nutritional interventions or drug treatments.
What Does BOC Sciences Do?
BOC Sciences offers comprehensive fatty acid and derivative analysis services:
Rapid protein removal, internal standard addition, and lipid extraction from serum samples to ensure high sensitivity for low-abundance oxidized fatty acids.
Non-targeted analysis of fatty acids and oxidized lipids using LC-HRMS and MS/MS tandem mass spectrometry, with targeted quantification of key lipids.
Data processing including peak identification, alignment, and quantification, followed by analysis using LIPID MAPS and metabolic pathway databases.
Key Outcomes
Qualitatively and quantitatively identified over 300 fatty acids and derivatives, including various oxidized and short-chain fatty acids.
Found that specific ω-3 oxidized fatty acids are significantly positively correlated with insulin sensitivity, providing potential metabolic health biomarkers.
Generated visualized lipid pathway analysis reports, helping the research team clarify the relationship between lipid metabolism abnormalities and diabetes progression, offering data support for clinical interventions.
Publications
This section showcases academic publications from international research teams using BOC Sciences' products and services, highlighting our industry impact in lipid supply and R&D.
An advanced TALSPEAK concept for separating minor actinides. Part 2. Flowsheet test with actinide-spiked simulant. Solvent Extraction and Ion Exchange 35.6 (2017): 396-407. DOI: 10.1080/07366299.2017.1368945.
Development and validation of rapid and simultaneous method for determination of 12 hair-growth compounds in adulterated products by UHPLC–MS/MS. Forensic science international 284 (2018): 129-135. PMID: 29408720 DOI: 10.1016/j.forsciint.2017.12.042.
Cuban Policosanol (Raydel®) Exerts Higher Antioxidant and Anti-Glycation Activities than Chinese Policosanol (BOC Sciences) in Reconstituted High-Density Lipoproteins: In Vivo Anti-Inflammatory Activities in Zebrafish and Its Embryos. Pharmaceuticals 17.4 (2024): 406. DOI: 10.3390/ph17040406.
Hopanoids, like sterols, modulate dynamics, compaction, phase segregation and permeability of membranes. Biochimica et Biophysica Acta (BBA)-Biomembranes (2019): 183060. DOI: 10.1016/j.bbamem.2019.183060.
The long-chain monounsaturated cetoleic acid improves the efficiency of the n-3 fatty acid metabolic pathway in Atlantic salmon and human HepG2 cells. Br J Nutr. 2019; 122(7): 755-768. DOI: 10.1017/S0007114519001478.
Industry Distribution of Custom Lipid Synthesis Clients
"BOC Sciences supported our lipid nanoparticle project with precise synthesis of cationic lipids. Their team provided timely updates, high-purity materials, and detailed characterization data. Their technical expertise and responsiveness exceeded our expectations."
— Dr. James Carter, Formulation Scientist (USA)
"During a critical vaccine formulation study, we needed custom PEGylated lipids with strict purity requirements. BOC Sciences delivered on time, with excellent batch consistency and thorough documentation. Their professionalism is impressive."
— Ms. Emily Thompson, Bioprocess Development Lead (UK)
"We collaborated with BOC Sciences for large-scale synthesis of saturated phospholipids. The team ensured high reproducibility and provided analytical reports that met our regulatory standards. They are a reliable partner for complex lipid projects."
— Dr. Michael Berger, Lipid Chemistry Specialist (Germany)
"For our metabolic disease research, we required specific fatty acid derivatives. BOC Sciences not only synthesized the compounds accurately but also provided insightful technical guidance, making the project smooth and efficient."
— Ms. Olivia Martinez, Research Scientist (Spain)
"Facing tight timelines for a cGMP-grade lipid excipient order, BOC Sciences delivered high-quality lipids with complete regulatory documentation. Their communication and adherence to specifications gave us full confidence."
— Dr. Daniel Evans, Process Development Manager (France)
"Our study on sphingolipid analogs demanded both precision and flexibility. BOC Sciences provided custom synthesis, rapid troubleshooting, and comprehensive QC data. Their team is professional, knowledgeable, and highly dependable."
We use cookies to understand how you use our site and to improve the overall user experience. This includes personalizing content and advertising.
Read our
Privacy Policy
