Azido-PEG7-CH2COOH

Name: Azido-PEG7-CH2COOH
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Azido-PEGn-CH2COOH
Catalog NO.	BPG-0848
Product Name	Azido-PEG7-CH2COOH
CAS	1446411-32-0
Molecular Formula	C16H31N3O9
Molecular Weight	409.42

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Description	Azido-PEG7-CH2COOH is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.
Synonyms	N3-PEG7-CH2COOH; Azido-PEG7-acetic acid; 23-Azido-3,6,9,12,15,18,21-heptaoxatricosan-1-oic acid; 3,6,9,12,15,18,21-Heptaoxatricosan-1-oic acid, 23-azido-
IUPAC Name	2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
SMILES	C(COCCOCCOCCOCCOCCOCCOCC(=O)O)N=[N+]=[N-]
InChI	InChI=1S/C16H31N3O9/c17-19-18-1-2-22-3-4-23-5-6-24-7-8-25-9-10-26-11-12-27-13-14-28-15-16(20)21/h1-15H2,(H,20,21)
InChIKey	OHDHUWBOUOIMHQ-UHFFFAOYSA-N
Purity	≥95%
Storage	Store at 2-8°C

Azido-PEG7-CH2COOH, a versatile chemical compound with diverse applications in biochemistry and medicine, plays a pivotal role in various domains. Here are four key applications of Azido-PEG7-CH2COOH, presented with high perplexity and burstiness:

Bioconjugation: Central to click chemistry, Azido-PEG7-CH2COOH is a cornerstone in the conjugation of biomolecules like proteins and nucleic acids through azide-alkyne cycloaddition reactions. This process generates bioconjugates endowed with enhanced functionality and specificity. Additionally, the compound's PEGylation properties contribute to bolstering the solubility and stability of the resulting conjugates, adding a layer of complexity to their utility.

Drug Delivery: Leveraging Azido-PEG7-CH2COOH in the realm of drug delivery opens up avenues for crafting targeted delivery systems. The PEG7 segment imparts stealth properties to nanoparticles, enabling them to navigate through the immune system undetected. Furthermore, the azido group serves as a versatile attachment site for targeting ligands or therapeutic agents, steering drugs towards specific cells or tissues with precision and intricacy.

Surface Modification: An invaluable tool for enhancing the biocompatibility of biomaterial surfaces, Azido-PEG7-CH2COOH facilitates surface modifications that deter protein adsorption and cell adhesion, creating a protective anti-fouling layer. These modifications are particularly critical for medical devices, implants, and biosensors, where the compound's ability to fine-tune surface properties adds layers of complexity and sophistication to their functionality.

Diagnostics: Azido-PEG7-CH2COOH plays a crucial role in diagnostic assays, particularly in the creation of bioconjugates for imaging and detection purposes. By functionalizing the compound with diverse reporter molecules, such as fluorophores or contrast agents, precise and efficient labeling of biomarkers is achieved, enhancing the sensitivity and accuracy of diagnostic applications. This intricate interplay of molecules underscores the compound's significance in advancing diagnostic technologies.

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