Azido-PEG9-amine

Name: Azido-PEG9-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Azido-PEGn-amine
Catalog NO.	BPG-0836
Product Name	Azido-PEG9-amine
CAS	1207714-69-9
Molecular Formula	C20H42N4O9
Molecular Weight	482.58

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Description	Azido-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms	N3-PEG9-CH2CH2NH2; Azido-PEG9-NH2; N3-PEG9-NH2; 29-azido-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-amine; 1-Amino-29-azido-3,6,9,12,15,18,21,24,27-nonaoxanonacosane
IUPAC Name	2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
SMILES	C(COCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])N
InChI	InChI=1S/C20H42N4O9/c21-1-3-25-5-7-27-9-11-29-13-15-31-17-19-33-20-18-32-16-14-30-12-10-28-8-6-26-4-2-23-24-22/h1-21H2
InChIKey	QECAUUOGHAUEDJ-UHFFFAOYSA-N
Purity	≥95%
Solubility	Soluble in DCM, DMF, DMSO, Water
Appearance	Colorless Oily Matter
Shelf Life	0-4°C for short term (days to weeks), or -20°C for long term (months).
Storage	Store at 2-8°C
LogP	-3.23

Azido-PEG9-amine, a versatile compound utilized extensively in chemical biology and bioconjugation techniques, boasts a wide array of applications. Here are four key applications presented with high perplexity and burstiness:

Bioconjugation: Serving as a pivotal tool in bioconjugation, Azido-PEG9-amine finds widespread use in linking biomolecules to synthetic compounds like drugs, fluorescent dyes, or nanoparticles. The azido group selectively reacts with alkynes in a copper-catalyzed click chemistry reaction, forming stable triazole linkages. This enables researchers to craft tailored and functional bio-conjugates for diverse applications, including imaging and targeted drug delivery.

Protein Labeling: In the realm of proteomics, Azido-PEG9-amine plays a crucial role in labeling proteins through site-specific modification. The polyethylene glycol (PEG) spacer offers flexibility and reduces steric hindrance, ensuring efficient conjugation of the azido group to target proteins. This facilitates the exploration of protein interactions, localization, and function within cellular processes, shedding light on the intricate workings of biological systems.

Drug Delivery Systems: Azido-PEG9-amine contributes to the development of cutting-edge drug delivery systems by enhancing solubility, stability, and bioavailability of drug molecules. Through conjugation of therapeutic agents to targeting moieties via click chemistry, researchers can create more potent and controlled release drug formulations, paving the way for improved treatment efficacy.

Surface Functionalization: Employed in the functionalization of surfaces such as nanoparticles, microarrays, and biosensors, Azido-PEG9-amine plays a vital role in enhancing detection systems' specificity and sensitivity. The azido group serves as a key element in attaching various molecules to surfaces, advancing the development of sophisticated diagnostic tools and biosensors with heightened performance capabilities.

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