Benzyl-PEG5-amine

Name: Benzyl-PEG5-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Benzyl-PEGn-NH2
Catalog NO.	BPG-1968
Product Name	Benzyl-PEG5-amine
CAS	86770-77-6
Molecular Formula	C17H29NO5
Molecular Weight	327.42

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Description	Benzyl-PEG5-amine is a polyethylene glycol (PEG)-based PROTAC linker. Benzyl-PEG5-amine can be used in the synthesis of a series of PROTACs.
Synonyms	Benzyl-PEG5-NH2; 1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-amine; 2,5,8,11,14-Pentaoxahexadecan-16-amine, 1-phenyl-; BnO-PEG4-CH2CH2NH2; 2-(2-{2-[2-(2-Benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethylamine
IUPAC Name	2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine
SMILES	C1=CC=C(C=C1)COCCOCCOCCOCCOCCN
InChI	InChI=1S/C17H29NO5/c18-6-7-19-8-9-20-10-11-21-12-13-22-14-15-23-16-17-4-2-1-3-5-17/h1-5H,6-16,18H2
InChIKey	OOHIPYDPAMVVIQ-UHFFFAOYSA-N
Boiling Point	429.7±40.0°C at 760 mmHg
Purity	>95%
Density	1.1±0.1 g/cm3
Solubility	Soluble in DCM, DMF, DMSO, Water
Appearance	Pale Yellow or Colorless Oily Liquid
Storage	Store at 2-8°C

Benzyl-PEG5-amine is a versatile reagent widely used in biochemical and biotechnological applications. Here are some key applications of Benzyl-PEG5-amine:

Drug Delivery Systems: Benzyl-PEG5-amine is employed in the development of polymer-drug conjugates for targeted drug delivery. The PEG (polyethylene glycol) component enhances the solubility and stability of the conjugates while reducing immunogenicity. By attaching therapeutic agents to Benzyl-PEG5-amine, drugs can be delivered more efficiently to specific tissues or cells.

Protein Modification: Benzyl-PEG5-amine is used in protein pegylation, a process where PEG chains are attached to proteins to improve their pharmacokinetic properties. This modification can increase a protein's solubility, reduce degradation, and enhance its half-life in the bloodstream. Pegylated proteins are often used in therapeutic applications, including enzyme replacement therapies and biologics.

Surface Functionalization: In the field of material science, Benzyl-PEG5-amine is utilized to modify surfaces and create biocompatible coatings. By grafting Benzyl-PEG5-amine onto surfaces, researchers can prevent nonspecific protein adsorption and cell adhesion. This application is crucial for developing biomedical devices, implants, and diagnostic tools that require non-fouling properties.

Bioconjugation: Benzyl-PEG5-amine serves as a linker in bioconjugation techniques, where it is used to connect biomolecules such as antibodies, enzymes, or nucleic acids. The amine group can react with carboxyl or other functional groups to form stable conjugates without affecting the biological activity of the molecules. This is valuable in creating targeted therapeutics, diagnostics, and biosensors.

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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.