Biotin-PEG6-NH-Mal

Name: Biotin-PEG6-NH-Mal
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Biotin PEG
Catalog NO.	BPG-2489
Product Name	Biotin-PEG6-NH-Mal
CAS	1808990-66-0
Molecular Formula	C₃₁H₅₁N₅O₁₁S
Molecular Weight	701.83

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Description	Biotin-PEG6-Mal is a polyethylene glycol (PEG)-based PROTAC linker. Biotin-PEG6-Mal can be used in the synthesis of a series of PROTACs.
Synonyms	(+)-Biotin-PEG6-NH-Mal; Biotin-PEG6-Mal; Biotin-PEG6-Maleimide; (+)-Biotin-PEG6-Maleimide
IUPAC Name	5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide
SMILES	C1C2C(C(S1)CCCCC(=O)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCN3C(=O)C=CC3=O)NC(=O)N2
InChI	InChI=1S/C31H51N5O11S/c37-26(4-2-1-3-25-30-24(23-48-25)34-31(41)35-30)32-8-11-42-13-15-44-17-19-46-21-22-47-20-18-45-16-14-43-12-9-33-27(38)7-10-36-28(39)5-6-29(36)40/h5-6,24-25,30H,1-4,7-23H2,(H,32,37)(H,33,38)(H2,34,35,41)/t24-,25-,30-/m0/s1
InChIKey	ILVNKONXZBFCPD-QRQMUESOSA-N
Purity	>97%
Appearance	White Solid
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

Biotin-PEG6-NH-Mal, a versatile bifunctional reagent, finds extensive use in biochemical and biomedical research. Here are four key applications of Biotin-PEG6-NH-Mal, presented with high perplexity and burstiness:

Bioconjugation: Widely employed in protein bioconjugation, Biotin-PEG6-NH-Mal serves as a crucial tool for linking proteins, peptides, and other molecules to Biotin. The maleimide group, with its affinity for thiol groups on target molecules, allows for precise site-specific conjugation. This process yields highly functionalized biotinylated compounds, essential for subsequent detection or purification procedures, showcasing the intricate dance of molecular interactions in biochemical research.

Protein Labeling and Detection: In the realm of protein analysis, Biotin-PEG6-NH-Mal plays a pivotal role in labeling proteins for detection and quantification in diverse assays. The inclusion of biotin enables strong binding to streptavidin or avidin, paving the way for the development of ultra-sensitive detection systems. This capability proves indispensable in assays like ELISA and Western blotting, where the intricate tracking of protein interactions demands meticulous attention to detail and specificity.

Surface Modification: Delving into surface science, Biotin-PEG6-NH-Mal emerges as a key player in surface modification, particularly in the realm of biotinylation for biomolecule immobilization. This process aids in enhancing surface functionality by enabling the capture of streptavidin-conjugated components on various substrates. Such modified surfaces find application in biosensor development, where precise monitoring of interactions with target molecules is critical, showcasing the sophisticated interplay between materials science and biological applications.

Drug Delivery Systems: Venturing into the frontier of drug delivery research, Biotin-PEG6-NH-Mal emerges as a promising candidate for modifying drugs or nanoparticles for targeted delivery. Leveraging the biotin-streptavidin interaction, researchers can guide therapeutic agents to specific cells or tissues, enhancing efficacy while minimizing off-target effects. This tailored approach heralds a new era in the development of precise and effective therapeutic strategies.

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