Bis-sulfone NHS Ester

Name: Bis-sulfone NHS Ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Small-molecule NHS ester PEG
Catalog NO.	BPG-4397
Product Name	Bis-sulfone NHS Ester
CAS	899452-51-8
Molecular Formula	C29H27NO9S2
Molecular Weight	597.7

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Description	Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. Please contact us for GMP-grade inquiries.
Synonyms	Bis-sulfone NHS Ester; 899452-51-8; 2,5-Dioxopyrrolidin-1-yl 4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoate; 4-[2,2-bis[(p-tolylsulfonyl)-methyl]acetyl]benzoic acid N-succinimidyl ester; 4-[2,2-bis[(p-tolylsulfonyl)-methyl]acetyl]benzoic acid-N-hydroxy succinimidyl ester; SCHEMBL17993598; MFCD30458024; (2,5-dioxopyrrolidin-1-yl) 4-[3-(4-methylphenyl)sulfonyl-2-[(4-methylphenyl)sulfonylmethyl]propanoyl]benzoate
IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 4-[3-(4-methylphenyl)sulfonyl-2-[(4-methylphenyl)sulfonylmethyl]propanoyl]benzoate
SMILES	CC1=CC=C(C=C1)S(=O)(=O)CC(CS(=O)(=O)C2=CC=C(C=C2)C)C(=O)C3=CC=C(C=C3)C(=O)ON4C(=O)CCC4=O
InChI	InChI=1S/C29H27NO9S2/c1-19-3-11-24(12-4-19)40(35,36)17-23(18-41(37,38)25-13-5-20(2)6-14-25)28(33)21-7-9-22(10-8-21)29(34)39-30-26(31)15-16-27(30)32/h3-14,23H,15-18H2,1-2H3
InChIKey	NTRPBIATANVSPI-UHFFFAOYSA-N
Purity	0.95
Storage	-20°C

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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.