Br-PEG6-NHBoc

Name: Br-PEG6-NHBoc
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Br-PEGn-NHBoc
Catalog NO.	BPG-0149
Product Name	Br-PEG6-NHBoc
Molecular Formula	C19H38BrNO8
Molecular Weight	488.42

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Description	Br-PEG6-NHBoc is a PEG linker containing a bromide group and a Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Synonyms	t-Boc-N-amido-PEG6-bromide; Boc-NH-PEG6-Br; BocNH-PEG6-CH2CH2Br; N-Boc-PEG6-bromide; Br-PEG6-C2-NHBoc; 2-Methyl-2-propanyl (20-bromo-3,6,9,12,15,18-hexaoxaicos-1-yl)carbamate; Carbamic acid, N-(20-bromo-3,6,9,12,15,18-hexaoxaeicos-1-yl)-, 1,1-dimethylethyl ester; tert-butyl (20-bromo-3,6,9,12,15,18-hexaoxaicosyl)carbamate
IUPAC Name	tert-butyl N-[2-[2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate
SMILES	CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCBr
InChI	InChI=1S/C19H38BrNO8/c1-19(2,3)29-18(22)21-5-7-24-9-11-26-13-15-28-17-16-27-14-12-25-10-8-23-6-4-20/h4-17H2,1-3H3,(H,21,22)
InChIKey	IKFUKQOSGQPPAB-UHFFFAOYSA-N
Boiling Point	528.4±50.0°C at 760 mmHg
Purity	≥95%
Density	1.2±0.1 g/cm3
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

Br-PEG6-NHBoc, a versatile reagent with wide-ranging applications in chemical synthesis and bioconjugation, serves as a key component in various fields. Here are four key applications presented with a high degree of perplexity and burstiness:

Drug Delivery Systems: Acting as a crucial link in drug delivery systems, Br-PEG6-NHBoc plays a pivotal role in enhancing the solubility and bioavailability of therapeutic agents. By conjugating with drugs, it elevates their stability and prolongs their circulation time in the bloodstream, leading to a more precise and efficient delivery to targeted tissues or cells.

Protein Modification: In the realm of protein modification, Br-PEG6-NHBoc emerges as a game-changer by boosting the pharmacokinetics and efficacy of therapeutic proteins. Through the attachment of PEG chains to proteins, it mitigates immunogenic responses and proteolytic breakdown, resulting in prolonged and heightened effectiveness of protein-based treatments.

Bioconjugation: The strategic utilization of Br-PEG6-NHBoc in bioconjugation processes enables the linkage of biomolecules like peptides, antibodies, or oligonucleotides to diverse molecules or surfaces. This integration is vital for crafting diagnostic tools, biosensors, and innovative therapeutics. The PEG spacer confers flexibility, reducing steric hindrances and ensuring seamless conjugation and optimal functionality of the biomolecules.

Material Science: Stepping into the realm of material science, Br-PEG6-NHBoc finds its place in the synthesis of PEGylated surfaces and nanoparticles. These tailored materials hold promise for applications in medical devices, tissue engineering, and controlled release systems. Through PEGylation, biocompatible and non-fouling surfaces are crafted, resisting protein adsorption and cellular adhesion, thus advancing the frontiers of material science and biotechnology.

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