BrCH2CONH-PEG1-acid

Name: BrCH2CONH-PEG1-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	BrCH2CONH-PEGn-acid
Catalog NO.	BPG-1317
Product Name	BrCH2CONH-PEG1-acid
Molecular Formula	C7H12BrNO4
Molecular Weight	254.08

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Description	BrCH2CONH-PEG1-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
Synonyms	Bromoacetamido-PEG1-C2-acid; Bromoacetamido-PEG1-CH2CH2COOH; Bromoacetamido-PEG1-acid; 3-(2-(2-bromoacetamido)ethoxy)propanoic acid
IUPAC Name	3-[2-[(2-bromoacetyl)amino]ethoxy]propanoic acid
SMILES	O=C(O)CCOCCNC(CBr)=O
InChI	InChI=1S/C7H12BrNO4/c8-5-6(10)9-2-4-13-3-1-7(11)12/h1-5H2,(H,9,10)(H,11,12)
InChIKey	QBSMINHHTOPNDS-UHFFFAOYSA-N
Purity	≥95%
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

BrCH2CONH-PEG1-acid is a bifunctional polyethylene glycol (PEG) derivative with significant versatility in biological and chemical applications. Here are some key applications of BrCH2CONH-PEG1-acid:

Bioconjugation: BrCH2CONH-PEG1-acid can be used to modify biomolecules, such as proteins, peptides, or antibodies, through PEGylation. This process enhances the solubility, stability, and circulating half-life of therapeutic proteins and drugs. The terminal acid group allows for further conjugation to other functional groups or surfaces, facilitating targeted delivery or imaging.

Surface Coating: This PEG derivative is useful in creating biocompatible and antifouling coatings on various surfaces, such as biomedical devices or nanoparticles. The PEGylation reduces protein adsorption and cellular adhesion, minimizing immune recognition and biofouling. Such coatings are essential in improving the performance and longevity of implants and diagnostic tools.

Drug Delivery: BrCH2CONH-PEG1-acid can be employed in the development of drug delivery systems, particularly for attaching drugs to carrier molecules. The PEG chain enhances the solubility and biocompatibility of hydrophobic drugs, improving their biodistribution and efficacy. This strategy is useful in designing targeted delivery systems that release drugs at specific sites within the body.

Chemical Synthesis: In organic chemistry, BrCH2CONH-PEG1-acid serves as a versatile building block for synthesizing more complex PEG-based structures. The bromine (Br) functionality can participate in various covalent bond-forming reactions, such as nucleophilic substitutions or coupling reactions. This enables the creation of tailor-made PEGylated compounds for diverse research and industrial applications.

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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.