DOPE

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Category	Phospholipid
Catalog NO.	BPG-3885
Product Name	DOPE
CAS	4004-05-1
Molecular Formula	C41H78NO8P
Molecular Weight	744.05

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Catalog Number	Name	Size / Price	Stock	Quantity
BPG-3885	DOPE		In stock

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Description	DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) is a zwitterionic phospholipid with two unsaturated oleoyl chains, imparting high fusogenicity and a tendency to form non-lamellar structures under certain conditions. These characteristics make DOPE particularly valuable in liposome formulations designed for cargo release, as it promotes membrane destabilization and fusion in response to environmental triggers. It is extensively used in gene delivery and as a helper lipid in nanoparticle systems where efficient endosomal escape is required.
Synonyms	18:1 PE; 1,2-Dioleoyl-sn-glycero-3-PE; 1,2-Dioleoyl-sn-glycero-3-Phosphoethanolamine; 1,2-DOPE; PE(18:1/18:1); Phophatidylethanolamine(18:1n9/18:1n9); Phophatidylethanolamine(18:1w9/18:1w9); 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; PE(18:1(9Z)/18:1(9Z)); 2-Aminoethyl (R)-2,3-Bis(oleoyloxy)propyl Hydrogen Phosphate; Olein, 1,2-di-, 2-aminoethyl hydrogen phosphate, L-; 9-Octadecenoic acid (9Z)-, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
IUPAC Name	[(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
SMILES	CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)OCCN)OC(=O)CCCCCCCC=CCCCCCCCC
InChI	InChI=1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1
InChIKey	MWRBNPKJOOWZPW-NYVOMTAGSA-N
Boiling Point	759.2±70.0 °C at 760 mmHg
Melting Point	200 °C
Purity	≥95%
Density	1.008±0.06 g/cm3 (Predicted)
Solubility	Soluble in Chloroform, DMSO
Appearance	White to light yellow to light orange freeze-dried powder
Shelf Life	≥2 years
Storage	Store at -20 °C

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