m-PEG8-COOH

Name: m-PEG8-COOH
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	m-PEGn-acid
Catalog NO.	BPG-2108
Product Name	m-PEG8-COOH
CAS	1093647-41-6
Molecular Formula	C18H36O10
Molecular Weight	412.47

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Description	m-PEG8-COOH offers a longer PEG linker with terminal carboxylic acid functionality, facilitating controlled payload attachment in ADC synthesis. It improves hydrophilicity and stability of bioconjugates, enhancing pharmacokinetic profiles.
Synonyms	mPEG7-propionic acid; m-PEG8-acid; 4,7,10,13,16,19,22,25-Octaoxahexacosanoic acid; mPEG7-CH2CH2COOH; 2,5,8,11,14,17,20,23-Octaoxahexacosan-26-oic acid; MPEG7-OCH2CH2COOH
IUPAC Name	3-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
SMILES	COCCOCCOCCOCCOCCOCCOCCOCCC(=O)O
InChI	InChI=1S/C18H36O10/c1-21-4-5-23-8-9-25-12-13-27-16-17-28-15-14-26-11-10-24-7-6-22-3-2-18(19)20/h2-17H2,1H3,(H,19,20)
InChIKey	JHUSQXBQANBSDC-UHFFFAOYSA-N
Boiling Point	503.0±50.0 °C at 760 mmHg
Flash Point	164.2±23.6 °C
Purity	≥95%
Density	1.111±0.06 g/cm3 (Predicted)
Solubility	Soluble in DCM, DMF, DMSO, Water
Appearance	Pale Yellow Oily Liquid
Storage	Store at 2-8°C
Exact Mass	412.23084734
Vapor Pressure	0.0±2.8 mmHg at 25°C
LogP	-2.78

m-PEG8-COOH, or methoxy polyethylene glycol with a carboxyl group, is a versatile reagent widely used in biomedical and biotechnological applications. Here are some key applications of m-PEG8-COOH:

Drug Delivery: m-PEG8-COOH is frequently used to modify therapeutic molecules for improved drug delivery. By attaching polyethylene glycol (PEG) chains to drugs, their solubility and stability can be enhanced, reducing immunogenicity and increasing circulation time in the bloodstream. This optimization can result in more effective and sustained drug therapies.

Bioconjugation: In bioconjugation, m-PEG8-COOH serves as a linker to attach various biomolecules, such as peptides, proteins, and antibodies, to surfaces or other molecules. The carboxyl group can form covalent bonds with amines, facilitating the creation of targeted drug delivery systems, diagnostic agents, and biosensors. This conjugation increases the functional versatility of biomolecules in numerous applications.

Surface Modification: m-PEG8-COOH can be used to modify the surfaces of medical devices and implants to improve biocompatibility and reduce protein and cell adhesion. This modification helps in minimizing immune responses and biofouling, thereby enhancing the performance and longevity of biomedical devices. It is particularly useful in applications like catheter coatings and stent surface treatments.

Polymer Therapeutics: m-PEG8-COOH is employed in the design of polymer therapeutics, where PEGylated polymers are engineered to deliver active pharmaceutical ingredients. By incorporating m-PEG8-COOH, these polymers can achieve controlled release, targeted delivery, and improved therapeutic indexes. This approach is valuable in the development of novel drug formulations and therapeutic strategies.

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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.