mPEG12-bromide

Name: mPEG12-bromide
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	m-PEGn-Br
Catalog NO.	BPG-2418
Product Name	mPEG12-bromide
CAS	1620461-89-3
Molecular Formula	C25H51BrO12
Molecular Weight	623.57

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Description	mPEG12-bromide is a PEG derivative that is used for PEGylation. The bromide can be replaced by nuleophilic reagents for bioconjugation and PEGylation.
Synonyms	m-PEG12-Br; m-PEG12-bromide; 2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxaheptatriacontane, 37-bromo-; Br-(CH2CH2O)12-Me; Bromo-PEG12-methoxy; 37-Bromo-2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontane
IUPAC Name	1-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-methoxyethane
SMILES	COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCBr
InChI	InChI=1S/C25H51BrO12/c1-27-4-5-29-8-9-31-12-13-33-16-17-35-20-21-37-24-25-38-23-22-36-19-18-34-15-14-32-11-10-30-7-6-28-3-2-26/h2-25H2,1H3
InChIKey	PRKRQHNXAMEUPI-UHFFFAOYSA-N
Boiling Point	595.6±0.0°C at 760 mmHg
Purity	>95%
Density	1.2±0.0 g/cm3
Appearance	Pale Yellow Oily Liquid
Storage	Store at 2-8°C

mPEG12-bromide, a versatile compound renowned for its capacity to modify molecules with polyethylene glycol (PEG) chains, finds diverse applications in the realm of biochemistry. Here are four key applications of mPEG12-bromide, presented with high perplexity and burstiness:

Drug Delivery: Embraced extensively in drug delivery systems, mPEG12-bromide plays a pivotal role in augmenting the solubility, stability, and bioavailability of pharmaceutical compounds. Through the conjugation of drugs with mPEG12-bromide, researchers can curtail drug clearance rates and prolong the therapeutic effect.

Protein Modification: In the intricate realm of protein biochemistry, mPEG12-bromide emerges as a key player in modifying proteins and peptides to enhance their pharmacokinetic properties. By PEGylating proteins with mPEG12-bromide, scientists can bolster their stability, diminish proteolytic degradation, and attenuate immunogenic responses. This transformation renders PEGylated proteins more suited for therapeutic applications, enabling them to circulate for extended periods within the bloodstream.

Surface Functionalization: Delving into the frontier of biomedical applications, mPEG12-bromide finds utility in surface functionalization processes. By affixing PEG chains to surfaces, it facilitates the reduction of protein adsorption and cellular adhesion, a critical aspect in crafting biocompatible materials. This application holds particular significance in the realm of medical devices, biosensors, and implantable materials.

Bioconjugation: Unveiling its prowess in various bioconjugation techniques, mPEG12-bromide emerges as a cornerstone in linking biomolecules such as peptides, proteins, and antibodies to diverse molecules or surfaces. This capability enables the creation of intricate bioconjugates for diagnostic assays, targeted drug delivery, and therapeutic advancements. The versatility of mPEG12-bromide in forming stable conjugates underscores its indispensable role in driving biochemical research and development towards new frontiers of discovery.

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