PFB-mercaptopropionyl-TOTA-Biotinyl
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| Category | Biotin PEG |
| Catalog NO. | BPG-4846 |
| Product Name | PFB-mercaptopropionyl-TOTA-Biotinyl |
| Molecular Formula | C35H41F9N4O6S2 |
| Molecular Weight | 848.84 |
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Product Information
| Description | PFB-mercaptopropionyl-TOTA-Biotinyl is a multifunctional linker designed for site-selective cysteine conjugation via π-Clamp-mediated chemistry. It combines a perfluorobiphenyl (PFB) group for π-π stacking interactions, a mercaptopropionyl moiety for thiol-reactive coupling, a TOTA (trioxatridecanyl) spacer for enhanced flexibility and solubility, and a biotin group for high-affinity binding to streptavidin. This structure enables precise modification of peptides or proteins at specific sites, facilitating applications in bioconjugation, peptide macrocyclization, and biomolecule labeling. |
| Synonyms | PFB-mercaptopropionyl-N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide; Perfluorobiphenyl-mercaptopropionyl-TOTA-Biotin |
| IUPAC Name | N-(15-oxo-17-((perfluoro-[1,1'-biphenyl]-4-yl)thio)-4,7,10-trioxa-14-azaheptadecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide |
| SMILES | FC1=C(F)C(SCCC(NCCCOCCOCCOCCCNC(CCCC[C@H]2[C@]([H])([C@]([H])(CS2)N3)NC3=O)=O)=O)=C(F)C(F)=C1C4=C(F)C(F)=C(F)C(F)=C4F |
| InChI | InChI=1S/C35H41F9N4O6S2/c36-24-22(25(37)29(41)30(42)28(24)40)23-26(38)31(43)34(32(44)27(23)39)55-16-7-21(50)46-9-4-11-53-13-15-54-14-12-52-10-3-8-45-20(49)6-2-1-5-19-33-18(17-56-19)47-35(51)48-33/h18-19,33H,1-17H2,(H,45,49)(H,46,50)(H2,47,48,51)/t18-,19-,33-/m0/s1 |
| InChIKey | GQBYQKVIZLYPNH-IQAJRQQCSA-N |
| Purity | >98% |
| Storage | Store at -20 °C |
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