S-acetyl-PEG3-acid

Name: S-acetyl-PEG3-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	AcS-PEGn-acid
Catalog NO.	BPG-1882
Product Name	S-acetyl-PEG3-acid
CAS	1421933-33-6
Molecular Formula	C11H20O6S
Molecular Weight	280.34

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Description	S-Acetyl-PEG3-C2-acid is a polyethylene glycol (PEG)-based PROTAC linker. S-Acetyl-PEG3-C2-acid can be used in the synthesis of a series of PROTACs.
Synonyms	S-acetyl-PEG3-COOH; S-Acetyl-PEG3-C2-acid; 14-Oxo-4,7,10-trioxa-13-thiapentadecanoic acid; 4,7,10-Trioxa-13-thiapentadecanoic acid, 14-oxo-; 2-Oxo-6,9,12-trioxa-3-thiapentadecan-15-oic acid; 6,9,12-Trioxa-3-thiapentadecan-15-oic acid, 2-oxo-; AcS-PEG3-acid
IUPAC Name	3-[2-[2-(2-acetylsulfanylethoxy)ethoxy]ethoxy]propanoic acid
SMILES	CC(=O)SCCOCCOCCOCCC(=O)O
InChI	InChI=1S/C11H20O6S/c1-10(12)18-9-8-17-7-6-16-5-4-15-3-2-11(13)14/h2-9H2,1H3,(H,13,14)
InChIKey	HJNQYRKIZPTUQT-UHFFFAOYSA-N
Boiling Point	421.4±40.0 °C at 760 mmHg
Purity	≥95%
Density	1.193±0.06 g/cm3 (Predicted)
Solubility	Soluble in DCM, DMF, DMSO, Water
Related CAS	956497-30-6 (polymer)
Appearance	Pale Yellow or Colorless Oily Liquid
Storage	Store at 2-8°C

S-acetyl-PEG3-acid, a versatile reagent utilized in bioconjugation and drug delivery applications, presents a plethora of opportunities. Here are four key applications showcased with a high degree of perplexity and burstiness:

Drug Delivery Systems: A multifaceted player, S-acetyl-PEG3-acid significantly enhances the solubility and stability of pharmaceutical compounds. By conjugating this reagent with drugs, researchers can optimize their pharmacokinetic profiles and dampen immunogenic responses. This strategic approach facilitates the more effective delivery of therapeutic agents, reducing potential side effects and maximizing efficacy.

Bioconjugation: Serving as a pivotal linker in the realm of bioconjugation, S-acetyl-PEG3-acid streamlines the attachment of biomolecules to a diverse array of surfaces or other biomolecules. This functionality is indispensable for crafting diagnostic tools, such as antibody-drug conjugates, and for immobilizing proteins on biosensors. The inherent flexibility of the PEG moiety alleviates steric hindrance, significantly augmenting the functionality of the final conjugates.

Protein Modification: In the realm of protein pegylation, S-acetyl-PEG3-acid plays a crucial role in modifying and enhancing the properties of proteins, impacting factors like solubility, immunogenicity, and in vivo half-life. These optimized proteins find application in various therapeutic settings, including enzyme replacement therapies and engineered antibodies, underscoring the potential for groundbreaking advancements in the field of medicine.

Surface Functionalization: Within the spheres of materials science and bioengineering, S-acetyl-PEG3-acid is harnessed for surface functionalization, offering an array of benefits. By incorporating this reagent onto surfaces, researchers can develop coatings that are biocompatible and resistant to fouling. These modified surfaces find diverse utility in applications ranging from biomedical devices and tissue engineering scaffolds to biosensors, enhancing performance and durability.

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