SPDP-PEG2-COOH
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| Category | SPDP-PEGn-COOH |
| Catalog NO. | BPG-3495 |
| Product Name | SPDP-PEG2-COOH |
| Molecular Formula | C15H22N2O5S2 |
| Molecular Weight | 374.47 |
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Product Information
| Description | SPDP-PEG2-COOH is a PEG-based PROTAC linker which is applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. It contains SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward amine and thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and DCC to form stable amide bonds. The water solubility properties of PEG linkers is enhanced by longer PEG chains. |
| Synonyms | SPDP-PEG2-acid; OPSS-PEG2-COOH; 3-(2-(2-(3-(pyridin-2-yldisulfaneyl)propanamido)ethoxy)ethoxy)propanoic acid |
| IUPAC Name | 3-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]propanoic acid |
| SMILES | O=C(O)CCOCCOCCNC(CCSSC1=NC=CC=C1)=O |
| InChI | InChI=1S/C15H22N2O5S2/c18-13(5-12-23-24-14-3-1-2-6-17-14)16-7-9-22-11-10-21-8-4-15(19)20/h1-3,6H,4-5,7-12H2,(H,16,18)(H,19,20) |
| InChIKey | WSGPIVSWTRUCJM-UHFFFAOYSA-N |
| Purity | ≥95% |
| Appearance | Light Yellow or White Solid |
| Storage | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.
PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS
PEG linkers For Drug
Improved Circulation Half-Life
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