THP-PEG6-alcohol

Name: THP-PEG6-alcohol
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	HO-PEGn-THP
Catalog NO.	BPG-2037
Product Name	THP-PEG6-alcohol
CAS	42607-87-4
Molecular Formula	C17H34O8
Molecular Weight	366.45

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Description	THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms	OH-PEG6-THP; HO-PEG6-THP; THP-PEG7; THP-PEG6-OH; 3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-[(tetrahydro-2H-pyran-2-yl)oxy]-; 17-((Tetrahydro-2H-pyran-2-yl)oxy)-3,6,9,12,15-pentaoxaheptadecan-1-ol
IUPAC Name	2-[2-[2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
SMILES	C1CCOC(C1)OCCOCCOCCOCCOCCOCCO
InChI	InChI=1S/C17H34O8/c18-4-6-19-7-8-20-9-10-21-11-12-22-13-14-23-15-16-25-17-3-1-2-5-24-17/h17-18H,1-16H2
InChIKey	ABJWCLPYMPRGRB-UHFFFAOYSA-N
Boiling Point	469.0±45.0 °C at 760 mmHg
Purity	≥95%
Density	1.10±0.1 g/cm3 (Predicted)
Solubility	Soluble in DMSO (10 mm)
Related CAS	92417-25-9 (polymer) 301295-36-3 (polymer)
Appearance	Solid
Shelf Life	-20°C 3 years powder; -80°C 2 years in solvent
Storage	Store at 2-8°C
LogP	0.90320

THP-PEG6-alcohol, a versatile chemical compound with applications in bioconjugation and drug delivery systems, serves as a cornerstone of innovation in these fields. Here are four key applications presented with high perplexity and burstiness:

Drug Delivery Systems: THP-PEG6-alcohol plays a pivotal role in the realm of drug delivery systems, where it is harnessed to modify drug molecules, enhancing their solubility and stability within biological systems. By conjugating drugs with PEG, it extends their circulation time in the bloodstream and mitigates immunogenic reactions. This strategic conjugation leads to enhanced therapeutic outcomes and decreased side effects, propelling advancements in medical treatments.

Surface Modification: A cornerstone of biotechnology, THP-PEG6-alcohol finds application in surface modification of medical devices and biomaterials to elevate their biocompatibility. The PEGylation process creates a hydrophilic shield around surfaces, diminishing protein adsorption and cellular adherence. This transformative process is integral in augmenting the durability and efficacy of implants and sensors, fostering sustainable progress in medical technology.

Bioconjugation: At the heart of bioconjugation techniques, THP-PEG6-alcohol serves as a vital linker for connecting biomolecules like proteins and peptides to diverse carriers or surfaces. This modulated attachment is fundamental for the advancement of targeted drug delivery systems, diagnostic tools, and therapeutic agents. It facilitates precise bonding and controlled release of biologically active compounds, driving forward the frontier of personalized medicine.

Protein Studies: Within the realm of protein studies, THP-PEG6-alcohol emerges as a game-changer in optimizing protein purification processes and stability assessments. PEGylation shields proteins from denaturation and degradation during handling and storage, preserving their integrity. Moreover, it enables the formulation of protein-based reagents with enhanced solubility and functional stability, revolutionizing research in molecular biology and biotechnology.

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