Small-molecule Methoxy Linear PEG (mPEG)

Small-molecule methoxy linear PEG (mPEG) is a polymer with a PEG chain with reactive groups at one end and a methoxy group at the other. It typically has a lower molecular weight and offers greater reactivity and modification flexibility. Small-molecule methoxy linear PEG (mPEG) has excellent solubility, biocompatibility, long cyclic half-life and modifiability, making it a promising candidate for a wide range of applications in drug delivery, nanomedicine, materials science, and biomedical research, etc.

BOC Sciences provides customers with high-purity, high-quality and homogeneous small-molecule methoxy linear PEG (mPEG) products. This type of polymer can be combined with various functional groups such as carboxyl, amino, azide, hydrazide, etc., which gives small-molecule methoxy linear PEG (mPEG) a wealth of functionalities.

Structural Features of Small-molecule Methoxy Linear PEG (mPEG)

• Linear structure - mPEG is a linear polymer with high flexibility and plasticity.
• Degree of polymerization - mPEG consists of glycol units (-OCH2CH2-) repeatedly linked, and the degree of polymerization can be adjusted as needed. The higher the degree of polymerization, the higher the molecular weight of the mPEG, and its physical and chemical properties will vary.
• Methoxy groups - Methoxy groups give mPEG good water solubility and biocompatibility, while also helping to modify its chemical reactivity and interactions.
• End groups - The end groups of mPEG can be chemically modified, which can adjust the properties and functions of mPEG.

Preparation of Small-molecule Methoxy Linear PEG (mPEG)

Advantages of Small-molecule Methoxy Linear PEG (mPEG)

• Permeability
  Small-molecule methoxy linear PEG (mPEG) has a relatively small molecular weight, which can penetrate biological barriers more easily and has a permeation enhancement effect, which can improve the efficiency and effectiveness of drug delivery.
• Reduce Drug Immunogenicity
  Small-molecule methoxy linear PEG (mPEG) reduces the interaction between the drug and the immune system by binding to the surface of the drug molecule, thus reducing the immunogenicity of the drug.
• Controlled Release Properties
  By adjusting the covalent binding or physical adsorption of small-molecule methoxy linear PEG (mPEG) to the drug, precise control of the rate and pattern of drug release can be achieved. This is important for the design and optimization of drug-controlled release systems to achieve sustained drug release and reduced drug dose frequency.

BOC Sciences offers mPEG derivatives with various functional groups such as amines (NH2), thiols (SH), azides (N3), NHS esters, maleimides (Mal), and more. You can find the ideal small-molecule methoxy linear PEG (mPEG) for the development of your project. If you don't find the product you need in our online catalog, contact us and we can provide you with a custom synthesis of the product.