Amino-PEG4-amine

Name: Amino-PEG4-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Amino-PEGn-amine
Catalog NO.	BPG-1811
Product Name	Amino-PEG4-amine
CAS	68960-97-4
Molecular Formula	C10H24N2O4
Molecular Weight	236.31

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Description	Amino-PEG4-C2-amine is a polyethylene glycol (PEG)-based PROTAC linker. Amino-PEG4-C2-amine can be used in the synthesis of a series of PROTACs.
Synonyms	3,6,9,12-Tetraoxatetradecane-1,14-diamine\|\|\|\|Triethylene Glycol Bis(2-aminoethyl) Ether
IUPAC Name	2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanamine
SMILES	C(COCCOCCOCCOCCN)N
InChI	InChI=1S/C10H24N2O4/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h1-12H2
InChIKey	IFZOPNLVYZYSMQ-UHFFFAOYSA-N
Boiling Point	139 °C/0.2 mmHg
Flash Point	157 °C
Purity	>97.0%(GC)
Density	1.0±0.1 g/cm3
Solubility	In DMSO: 120 mg/mL (507.81 mM; Need ultrasonic) In H2O: 120 mg/mL (507.81 mM; Need ultrasonic)
Appearance	Colorless to Light yellow clear liquid
Storage	0-10°C
Pictogram(s)	Corrosive, Irritant
Signal	Danger
Precautionary Statement Codes	P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501

Amino-PEG4-amine, a polyethylene glycol derivative with amine functional groups at both ends, is a versatile compound used in various scientific applications. Here are some key applications of Amino-PEG4-amine:

Bioconjugation: Amino-PEG4-amine is widely used in bioconjugation techniques to link biomolecules such as proteins, peptides, and antibodies to surfaces or other molecules. Its bifunctional amine groups facilitate covalent attachment, improving the stability and solubility of the conjugates. This is particularly useful in developing diagnostic assays, drug delivery systems, and biomaterials.

Drug Delivery: In drug delivery, Amino-PEG4-amine is employed to modify therapeutic agents, enhancing their pharmacokinetic and pharmacodynamic properties. By attaching PEG chains to drugs or nanoparticles, it provides stealth characteristics, reducing immune recognition and prolonging circulation time in the body. This targeted approach improves drug efficacy and minimizes side effects.

Surface Modification: Amino-PEG4-amine is used to modify surfaces of medical devices, biosensors, and nanomaterials to reduce non-specific binding and improve biocompatibility. By creating a hydrophilic PEG layer, it prevents protein adsorption and cellular adhesion, thereby enhancing the performance and longevity of the devices. This is essential in applications ranging from implantable devices to in vitro diagnostics.

Cross-Linking: Amino-PEG4-amine acts as a cross-linker in the synthesis of hydrogels and other polymeric networks. Its bifunctional nature allows it to form stable and flexible networks, which are used in tissue engineering, controlled release systems, and as scaffolds for cell growth. This versatile application enables the creation of materials with desirable mechanical and biological properties.

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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.