Amino-PEG4-propionic acid

Name: Amino-PEG4-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Amino-PEGn-COOH
Catalog NO.	BPG-1855
Product Name	Amino-PEG4-propionic acid
CAS	663921-15-1
Molecular Formula	C11H23NO6
Molecular Weight	265.30

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Description	Amino-PEG4-propionic acid is a medium-length PEG linker intermediate designed to improve antibody solubility and conjugation stability in ADCs. It enhances drug loading efficiency and supports controlled payload release for targeted therapies.
Synonyms	1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid; Amino-PEG4-acid; (PEO)4-amino-propionic acid
IUPAC Name	3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid
SMILES	C(COCCOCCOCCOCCN)C(=O)O
InChI	InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)
InChIKey	DKUZHSDZSMQOGQ-UHFFFAOYSA-N
Boiling Point	409.6±40.0 °C at 760 mmHg
Flash Point	201.5±27.3 °C
Purity	> 98.0 %
Density	1.1±0.1 g/cm3
Solubility	10 mm in DMSO
Related CAS	1818294-41-5 (polymer) 196936-04-6 (polymer)
Appearance	Solid
Storage	-20 °C
Exact Mass	265.15253745
Vapor Pressure	0.0±2.1 mmHg at 25°C
LogP	-1.92
Pictogram(s)	Irritant
Signal	Warning
Precautionary Statement Codes	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Amino-PEG4-propionic acid, a versatile compound with wide-ranging applications in biochemical and biotechnological fields, plays a pivotal role in various processes. Here are four key applications presented with high perplexity and burstiness:

Bioconjugation: Amino-PEG4-propionic acid serves as a cornerstone in bioconjugation strategies, enabling the linkage of biomolecules such as proteins, antibodies, and peptides via its functional amino group. This fosters the creation of durable bioconjugates essential for diagnostics, therapeutics, and biosensors. The inclusion of a PEG spacer enhances molecular solubility and stability while mitigating steric hindrance, elevating the quality of the resulting conjugates.

Drug Delivery Systems: Through PEGylation with Amino-PEG4-propionic acid, drugs undergo a transformation in their pharmacokinetic properties, bolstering solubility, diminishing immunogenicity, and extending circulation time within the bloodstream. This compound also finds utility in modifying drug delivery carriers like liposomes and nanoparticles, enhancing their biocompatibility and targeting precision for optimized drug delivery efficiency.

Surface Modification: The application of Amino-PEG4-propionic acid in surface modifications of diverse biomaterials for biomedical purposes yields substantial benefits. Integration onto surfaces such as implants and medical devices curbs unwanted protein adsorption and diminishes immune reactions, enhancing the biocompatibility and operational efficacy of medical devices, ultimately leading to improved patient outcomes.

Protein Purification: Leveraging the amino group within Amino-PEG4-propionic acid, researchers can establish affinity tags crucial for protein purification endeavors. By attaching this compound to proteins of interest, the capture and isolation of target proteins from intricate mixtures are expedited, ensuring the production of high-purity proteins vital for both research and therapeutic applications.

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