Azide-PEG5-Tos

Name: Azide-PEG5-Tos
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-2118
Product Name	Azide-PEG5-Tos
CAS	236754-49-7
Molecular Formula	C17H27N3O7S
Molecular Weight	417.48

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Description	Azide-PEG5-Tos is an ADC linker with PEG5 spacer and azide reactive group, designed for strain-promoted azide-alkyne cycloaddition. It enhances conjugation efficiency and improves stability in targeted antibody-drug conjugate synthesis.
Synonyms	14-Azido-3,6,9,12-tetraoxatetradecyl 4-methylbenzenesulfonate
IUPAC Name	2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
SMILES	CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOCCN=[N+]=[N-]
InChI	InChI=1S/C17H27N3O7S/c1-16-2-4-17(5-3-16)28(21,22)27-15-14-26-13-12-25-11-10-24-9-8-23-7-6-19-20-18/h2-5H,6-15H2,1H3
InChIKey	RCRFPWKHJGMATE-UHFFFAOYSA-N
Purity	>98.0%
Solubility	10 mm in DMSO
Appearance	Solid Power
Shelf Life	≥ 2 years
Storage	Store at -20 °C, keep in dry and avoid sunlight.
LogP	0.88

Azide-PEG5-Tos, a versatile bioconjugation reagent, is a staple in the realms of chemical biology and drug research, lauded for its adeptness in connecting molecules through click chemistry. Here are four key applications of Azide-PEG5-Tos, presented with high perplexity and burstiness:

Site-Specific Protein Labeling: Harnessing the power of Azide-PEG5-Tos, researchers can introduce an azide group into proteins, enabling selective labeling with an array of probes or drugs using copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. This precise methodology allows for the functionalization of proteins without compromising their natural activity. Scientists employ this technique for tracking, imaging, and scrutinizing the dynamic behaviors of proteins within live cells, delving into the intricacies of cellular processes.

Drug Delivery Systems: The utility of Azide-PEG5-Tos extends to the realm of targeted drug delivery systems, where it plays a pivotal role in conjugating therapeutic molecules to targeting ligands or nanoparticles via the azide group. This strategic conjugation ensures the accurate delivery of drugs to specific cells or tissues, bolstering therapeutic efficacy while minimizing side effects through localized drug action. This approach heralds a new era in precision medicine, as therapies are directed precisely where needed, optimizing treatment outcomes.

Polymer and Material Science: Within the domain of polymer and material science, Azide-PEG5-Tos serves as a linchpin for functionalizing surfaces and constructing polymer networks. The azide group's affinity for alkyne-functionalized materials facilitates the formation of robust covalent linkages through click chemistry, paving the way for the development of hydrogels, nanomaterials, and other bespoke materials with tailored properties. These advanced materials find applications in biomedical devices, tissue engineering, and controlled release systems, pushing the boundaries of material science innovation.

Bioorthogonal Chemistry: Azide-PEG5-Tos emerges as a cornerstone reagent in bioorthogonal chemistry, a domain dedicated to chemical reactions that transpire within living systems without disrupting native biochemical pathways. This reagent empowers scientists to label, track, and manipulate biomolecules within complex biological milieus, enabling real-time exploration of biological processes and the creation of cutting-edge diagnostics and therapeutics.

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