Bis-PEG2-t-butyl ester

Name: Bis-PEG2-t-butyl ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	COOtBu-PEGn-COOtBu
Catalog NO.	BPG-1573
Product Name	Bis-PEG2-t-butyl ester
CAS	1611468-28-0
Molecular Formula	C16H30O6
Molecular Weight	318.41

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Description	Bis-PEG2-t-butyl ester is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs.
Synonyms	Bis(2-methyl-2-propanyl) 3,3'-[1,2-ethanediylbis(oxy)]dipropanoate; Propanoic acid, 3,3'-[1,2-ethanediylbis(oxy)]bis-, 1,1'-bis(1,1-dimethylethyl) ester; Bis-PEG2-Boc; tert-butyl 3-{2-[3-(tert-butoxy)-3-oxopropoxy]ethoxy}propanoate
IUPAC Name	tert-butyl 3-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]propanoate
SMILES	CC(C)(C)OC(=O)CCOCCOCCC(=O)OC(C)(C)C
InChI	InChI=1S/C16H30O6/c1-15(2,3)21-13(17)7-9-19-11-12-20-10-8-14(18)22-16(4,5)6/h7-12H2,1-6H3
InChIKey	ALKAASHAFVQEJO-UHFFFAOYSA-N
Boiling Point	374.1±22.0°C (Predicted)
Purity	≥95%
Density	1.019±0.06 g/cm3 (Predicted)
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

Bis-PEG2-t-butyl ester, a versatile chemical compound renowned for its myriad functionalities in diverse biomedical applications, serves as a cornerstone in various cutting-edge domains. Here are four key applications:

Drug Delivery Systems: Positioned at the forefront of advanced drug delivery systems, Bis-PEG2-t-butyl ester emerges as a pivotal component orchestrating precise drug localization and enhancing treatment efficacy. By acting as a crucial linker molecule, this compound facilitates the coupling of therapeutic agents to carrier molecules like nanoparticles or liposomes, heralding a new era of targeted drug delivery with unparalleled precision and minimal adverse effects.

Protein PEGylation: Within the intricate realm of protein PEGylation, Bis-PEG2-t-butyl ester shines brightly, propelling the solubility and stability of protein-based drugs to unprecedented heights. This compound acts as a linchpin in the conjugation of polyethylene glycol (PEG) chains to proteins or peptides, prolonging their circulation in the bloodstream and optimizing pharmacokinetic properties. Such enhancements are integral in maximizing the efficacy of biologic drugs, ultimately leading to improved patient outcomes in clinical settings.

Bioconjugation: Embracing the complexities of bioconjugation techniques, Bis-PEG2-t-butyl ester assumes a significant role in the fusion of biomolecules, elevating the sensitivity and specificity of diagnostic assays and imaging studies. By linking antibodies to enzymes or fluorescent markers, this compound facilitates enhanced detection capabilities and diagnostic accuracies in diverse biotechnological and biomedical applications.

Surface Modification: Extending beyond its inherent functions, Bis-PEG2-t-butyl ester finds new avenues in the realm of surface modification for medical devices and biomaterials. By mitigating protein adsorption and cellular adhesion, this compound reduces the risk of biofouling, thereby enhancing biocompatibility and ensuring optimal performance and safety in clinical environments.

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