Bis-PEG3-t-butyl ester

Name: Bis-PEG3-t-butyl ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	COOtBu-PEGn-COOtBu
Catalog NO.	BPG-2029
Product Name	Bis-PEG3-t-butyl ester
CAS	1611468-29-1
Molecular Formula	C18H34O7
Molecular Weight	362.46

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Description	Bis-PEG3-t-butyl ester is a polyethylene glycol (PEG)-based PROTAC linker. Bis-PEG3-t-butyl ester can be used in the synthesis of a series of PROTACs.
Synonyms	OtBu-PEG3-OtBu; 2-Methyl-2-propanyl 2,2-dimethyl-4-oxo-3,7,10,13-tetraoxahexadecan-16-oate; 3,7,10,13-Tetraoxahexadecan-16-oic acid, 2,2-dimethyl-4-oxo-, 1,1-dimethylethyl ester
IUPAC Name	tert-butyl 3-[2-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]ethoxy]propanoate
SMILES	CC(C)(C)OC(=O)CCOCCOCCOCCC(=O)OC(C)(C)C
InChI	InChI=1S/C18H34O7/c1-17(2,3)24-15(19)7-9-21-11-13-23-14-12-22-10-8-16(20)25-18(4,5)6/h7-14H2,1-6H3
InChIKey	BIABJXAWGDLLJY-UHFFFAOYSA-N
Boiling Point	414.7±30.0°C at 760 mmHg
Purity	≥95%
Density	1.0±0.1 g/cm3
Appearance	Pale Yellow Oily Liquid
Storage	Store at 2-8°C

Bis-PEG3-t-butyl ester, a versatile bifunctional polyethylene glycol derivative, finds a myriad of applications in bioconjugation and drug delivery. Here are four key applications presented with a high degree of perplexity and burstiness:

Drug Delivery: A pinnacle of innovation, Bis-PEG3-t-butyl ester plays a pivotal role in crafting drug delivery systems that elevate the solubility and stability of therapeutic agents. The process of PEGylation not only enhances drug circulation time in the bloodstream but also mitigates their immunogenicity, facilitating precise targeting of drugs to specific tissues or cells for enhanced therapeutic efficacy.

Protein Conjugation: Within the realm of protein engineering, Bis-PEG3-t-butyl ester emerges as a transformative tool for enhancing the pharmacokinetic properties of proteins and reducing their immunogenicity. By attaching PEG chains to therapeutic proteins or enzymes, their stability and half-life undergo a remarkable extension, offering sustained activity crucial for therapeutic applications demanding prolonged efficacy.

Diagnostic Imaging: A game-changer in diagnostic imaging, this compound can be intricately conjugated to imaging agents, amplifying their solubility and biodistribution for superior imaging outcomes. PEGylation of contrast agents not only amplifies their retention time but also diminishes non-specific binding, culminating in sharper and more refined imaging results, thus spearheading the advancement of cutting-edge diagnostic tools in medical imaging.

Surface Modification: Stepping into the domain of surface modification, Bis-PEG3-t-butyl ester contributes to the creation of biocompatible coatings on medical devices and biomaterials. By integrating PEG chains into surfaces, a shield against protein adsorption and cell adhesion is erected, curtailing the risk of adverse reactions and heightening the performance and safety standards of implants, catheter systems, and other biomedical devices.

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