DOPE-Mal
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| Category | Phospholipid |
| Catalog NO. | BPG-3891 |
| Product Name | DOPE-Mal |
| CAS | 2295813-15-7 |
| Molecular Formula | C48H83N2O11P |
| Molecular Weight | 895.2 |
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Product Information
| Description | DOPE-Mal is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions with a terminal maliemide group. 1,2-DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media. Please contact us for GMP-grade inquiries. |
| Synonyms | DOPE-MAL; BP-28874; (2R)-3-(((2-(3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dioleate; 2295813-15-7 |
| IUPAC Name | [(2R)-3-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy-hydroxyphosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate |
| SMILES | CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)CCN1C(=O)C=CC1=O)OC(=O)CCCCCCCC=CCCCCCCCC |
| InChI | InChI=1S/C48H83N2O11P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-47(54)58-41-43(61-48(55)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)42-60-62(56,57)59-40-38-49-44(51)37-39-50-45(52)35-36-46(50)53/h17-20,35-36,43H,3-16,21-34,37-42H2,1-2H3,(H,49,51)(H,56,57)/b19-17-,20-18-/t43-/m1/s1 |
| InChIKey | LCNRIZXWHOCCGU-OYJIOEIKSA-N |
| Purity | 0.98 |
| Storage | -20°C |
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