Maleimido-tri(ethylene glycol)-propionic acid
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| Category | Mal-PEGn-acid |
| Catalog NO. | BPG-3581 |
| Product Name | Maleimido-tri(ethylene glycol)-propionic acid |
| CAS | 518044-40-1 |
| Molecular Formula | C13H19NO7 |
| Molecular Weight | 301.29 |
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Product Information
| Description | Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation. |
| Synonyms | Mal-PEG3-acid; Mal-PEG3-CH2CH2COOH; Mal-PEG3-COOH; Maleimide-PEG3-CH2CH2COOH; Mal-PEG3-propionic acid; 3-(2-(2-(2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethoxy)ethoxy)propanoic acid; 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid; Propanoic acid, 3-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]- |
| IUPAC Name | 3-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]propanoic acid |
| SMILES | C1=CC(=O)N(C1=O)C(CCO)C(CCO)(CCO)C(=O)O |
| InChI | InChI=1S/C13H19NO7/c15-6-3-9(14-10(18)1-2-11(14)19)13(4-7-16,5-8-17)12(20)21/h1-2,9,15-17H,3-8H2,(H,20,21) |
| InChIKey | AMOPUHDFPSFVHL-UHFFFAOYSA-N |
| Boiling Point | 491.4±40.0°C (Predicted) |
| Flash Point | 337.3±31.5 °C |
| Purity | ≥95% |
| Density | 1.293±0.06 g/cm3 (Predicted) |
| Solubility | Soluble in DMSO (10 mm) |
| Related CAS | 357277-61-3 (polymer) 2422928-26-3 (polymer) |
| Appearance | Pale Yellow Oily Matter |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| Storage | Store at 2-8°C |
| Vapor Pressure | 0.0±4.2 mmHg at 25°C |
| LogP | -1.29 |
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