Monophosphoryl Lipid A

Name: Monophosphoryl Lipid A
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Adjuvants
Catalog NO.	BPG-3010
Product Name	Monophosphoryl Lipid A
CAS	1246298-63-4
Molecular Formula	C96H184N3O22P
Molecular Weight	1763.47

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Description	Monophosphoryl Lipid A is a toll-like receptor 4 agonist with potential immunostimulatory activity, which is commonly used as a vaccine adjuvant.
Synonyms	MPLA (PHAD^®); phosphorylated hexaacyl disaccharide; Glycopyranoside Lipid A
IUPAC Name	azanium;[(2R,3S,4R,5R,6R)-6-[[(2R,3S,4R,5R,6S)-3,6-dihydroxy-5-[[(3R)-3-hydroxytetradecanoyl]amino]-4-[(3R)-3-hydroxytetradecanoyl]oxyoxan-2-yl]methoxy]-2-(hydroxymethyl)-5-[[(3R)-3-tetradecanoyloxytetradecanoyl]amino]-4-[(3R)-3-tetradecanoyloxytetradecanoyl]oxyoxan-3-yl] hydrogen phosphate
SMILES	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1OCC2C(C(C(C(O2)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC.N
InChI	InChI=1S/C96H181N2O22P.H3N/c1-7-13-19-25-31-37-39-45-51-57-63-69-85(104)114-79(67-61-55-49-43-35-29-23-17-11-5)73-84(103)98-90-94(119-88(107)74-80(68-62-56-50-44-36-30-24-18-12-6)115-86(105)70-64-58-52-46-40-38-32-26-20-14-8-2)92(120-121(110,111)112)81(75-99)117-96(90)113-76-82-91(108)93(118-87(106)72-78(101)66-60-54-48-42-34-28-22-16-10-4)89(95(109)116-82)97-83(102)71-77(100)65-59-53-47-41-33-27-21-15-9-3;/h77-82,89-96,99-101,108-109H,7-76H2,1-6H3,(H,97,102)(H,98,103)(H2,110,111,112);1H3/t77-,78-,79-,80-,81-,82-,89-,90-,91-,92-,93-,94-,95+,96-;/m1./s1
InChIKey	UPAZUDUZKTYFBG-HNPUZVNISA-N
Purity	> 99%
Related CAS	960324-04-3 (free acid)
Appearance	Powder
Shelf Life	1 Year
Storage	Store at -20°C
Exact Mass	1762.311
Hygroscopic	No
Light Sensitive	No
Percent Composition	C 65.38%, H 10.52%, N 2.38% ,O 19.96%, P 1.76
Pictogram(s)	Irritant, Health Hazard
Signal	Warning
Precautionary Statement Codes	P260, P261, P264, P270, P271, P304+P340, P308+P316, P319, P403+P233, P405, and P501

Monophosphoryl Lipid A (MPLA), a derivative of lipopolysaccharide (LPS), stands as a potent activator of the immune system with diverse scientific and medical uses. Below are four key applications of MPLA presented with high perplexity and burstiness:

Vaccine Adjuvant: MPLA functions as a crucial adjuvant in vaccines, amplifying the body's immune response to the target antigen. By fostering a more robust and enduring immunity, MPLA diminishes the necessity for repetitive booster doses. This integral role transforms MPLA into a cornerstone in crafting efficacious vaccines against infectious ailments such as HPV and hepatitis B.

Cancer Immunotherapy: In the realm of cancer immunotherapy, MPLA emerges as a key player in galvanizing the immune system to identify and combat cancer cells. By spurring innate immunity and facilitating dendritic cell maturation, MPLA augments the effectiveness of cancer vaccines. This stimulation leads to a vigorous anti-tumor immune reaction and elevates patient outcomes, marking a stride forward in cancer treatment.

Immunological Research: MPLA finds widespread utility in immunological research, delving into the intricacies of immune activation and modulation mechanisms. With its prowess in triggering specific Toll-like receptor 4 (TLR4) pathways, MPLA becomes an invaluable instrument for unraveling innate immune responses. Scientists harness MPLA to explore TLR4's involvement in various diseases and formulate novel immunomodulatory therapies, enriching our comprehension of immune system dynamics.

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