mPEG3-thiol

Name: mPEG3-thiol
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Small-molecule Methoxy Linear PEG (mPEG)
Catalog NO.	BPG-1724
Product Name	mPEG3-thiol
CAS	31521-83-2
Molecular Formula	C7H16O3S
Molecular Weight	180.27

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Description	m-PEG3-SH is a polyethylene glycol (PEG)-based PROTAC linker. m-PEG3-SH can be used in the synthesis of a series of PROTACs.
Synonyms	mPEG3-SH; 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol
IUPAC Name	2-[2-(2-methoxyethoxy)ethoxy]ethanethiol
SMILES	COCCOCCOCCS
InChI	InChI=1S/C7H16O3S/c1-8-2-3-9-4-5-10-6-7-11/h11H,2-7H2,1H3
InChIKey	DMFFSDWRRLCKKN-UHFFFAOYSA-N
Boiling Point	234.3±25.0 °C at 760 mmHg
Purity	>95%
Density	1.017 g/mL
Appearance	Colorless Liquid
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

mPEG3-thiol, a polyethylene glycol derivative featuring a thiol group, possesses remarkable utility in the realms of bioscience and medicine due to its exceptional chemical attributes. Here are four key applications of mPEG3-thiol:

Bioconjugation: Serving as a fundamental element in bioconjugation practices, mPEG3-thiol enables the linkage of biomolecules to diverse surfaces or other biomolecules via thiol-reactive entities. This pivotal process is essential for the creation of stable and functionalized nanoparticles, biosensors, and drug delivery systems. The capability of mPEG3-thiol to improve the biocompatibility and solubility of conjugated compounds proves invaluable in propelling forward biomedical research endeavors.

Protein Modification: In the realm of protein chemistry, mPEG3-thiol assumes a critical role in the process of pegylating proteins, involving the attachment of polyethylene glycol chains to proteins. Pegylation enhances the stability and solubility of proteins, reduces immunogenicity, and prolongs their circulation within the bloodstream. This modification stands as a cornerstone in the progression of protein-based therapeutic innovations, heralding a new era in the field of biomedicine.

Surface Coating: mPEG3-thiol stands as a stalwart in surface coating methodologies, particularly for surfaces like gold or silver nanoparticles that interact with thiol species. This specialized coating prevents nonspecific protein adherence and reduces immunogenicity, making nanoparticles more suitable for a variety of biomedical applications. The resilient and enduring attachment of the thiol group ensures consistent functionalization for a multitude of purposes, showcasing the versatility of mPEG3-thiol in endeavors related to surface engineering.

Diagnostic Tools: Within the realm of diagnostic tool development, mPEG3-thiol emerges as a pivotal component in enhancing the operational efficiency of diagnostic probes or sensors through surface modifications. By preventing unspecific binding and enhancing probe stability, mPEG3-thiol enhances sensitivity and specificity in diagnostic assays. This augmentation amplifies the precision and reliability of biomarker detection in clinical diagnostics, highlighting the crucial role that mPEG3-thiol plays in advancing healthcare diagnostics.

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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.