Propargyl-PEG3-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite

Name: Propargyl-PEG3-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-1995
Product Name	Propargyl-PEG3-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite
CAS	1391728-01-0
Molecular Formula	C₁₆H₂₉N₂O₄P
Molecular Weight	344.39

Propargyl-PEG3-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite

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Description	Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite is a polyethylene glycol (PEG)-based PROTAC linker. Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used in the synthesis of a series of PROTACs.
Synonyms	Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite; 1391728-01-0; Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite; 3-[[di(propan-2-yl)amino]-[2-(2-prop-2-ynoxyethoxy)ethoxy]phosphanyl]oxypropanenitrile; 5-[bis(propan-2-yl)amino]-4,6,9,12-tetraoxa-5-phosphapentadec-14-ynenitrile; AKOS040756720; HY-W096141; BP-22317
IUPAC Name	3-[[di(propan-2-yl)amino]-[2-(2-prop-2-ynoxyethoxy)ethoxy]phosphanyl]oxypropanenitrile
SMILES	CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCC#C
InChI	InChI=1S/C16H29N2O4P/c1-6-9-19-11-12-20-13-14-22-23(21-10-7-8-17)18(15(2)3)16(4)5/h1,15-16H,7,9-14H2,2-5H3
InChIKey	WEJZAWTVOQPXEP-UHFFFAOYSA-N
Purity	>95%
Appearance	Transparent Liquid
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

Propargyl-PEG3-1-O-(b-cyanoethyl-NN-diisopropyl)phosphoramidite, a versatile chemical reagent utilized in organic synthesis and biochemical research, boasts diverse applications showcased with a high degree of perplexity and burstiness.

Nucleic Acid Labeling: Delving into oligonucleotide synthesis, this reagent facilitates the incorporation of an alkyne functional group. This alkyne group subsequently engages in click chemistry reactions, enabling the attachment of various labels such as fluorescent dyes or biotin. This process streamlines the detection and purification of nucleic acids, playing a pivotal role in molecular diagnostics and genomics research endeavors.

Drug Delivery Systems: Showcasing its adaptability, Propargyl-PEG3-1-O-(b-cyanoethyl-NN-diisopropyl)phosphoramidite plays a crucial role in functionalizing drug delivery vectors like liposomes and nanoparticles with alkyne groups. This functionalization sets the stage for the conjugation of targeting ligands or therapeutic agents via click chemistry, thereby amplifying the specificity and efficacy of drug delivery mechanisms. Such enhancements are paramount for driving forward cutting-edge therapeutic solutions.

Bioconjugation: Serving as a valuable tool for creating bioconjugate molecules, this reagent streamlines the linking of biomolecules such as proteins, peptides, or small molecules through click reactions. This methodology is indispensable for generating functional protein conjugates essential for drug development, diagnostics, and various biotechnological applications. It ensures precise and stable attachment, optimizing biological activity and functionality.

Surface Immobilization: Facilitating surface modification with alkynes, Propargyl-PEG3-1-O-(b-cyanoethyl-NN-diisopropyl)phosphoramidite enables the covalent attachment of biomolecules via click chemistry. Widely employed in crafting biosensors, microarrays, and other bioanalytical devices, this technique guarantees high-density and oriented immobilization, thereby boosting detection sensitivity and accuracy.

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