Propargyl-PEG3-NHS ester

Name: Propargyl-PEG3-NHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-1943
Product Name	Propargyl-PEG3-NHS ester
CAS	1428629-71-3
Molecular Formula	C14H19NO7
Molecular Weight	313.30

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Description	Propargyl-PEG3-NHS ester is an alkyne-functionalized ADC linker used for amine-reactive and click-compatible conjugation. Its PEG3 spacer enhances hydrophilicity and flexibility, making it suitable for targeted drug delivery and antibody conjugate development.
Synonyms	Alkyne-PEG3-NHS;2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate
IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate
SMILES	C#CCOCCOCCOCCC(=O)ON1C(=O)CCC1=O
InChI	InChI=1S/C14H19NO7/c1-2-6-19-8-10-21-11-9-20-7-5-14(18)22-15-12(16)3-4-13(15)17/h1H,3-11H2
InChIKey	YDRPXORAOIYIGV-UHFFFAOYSA-N
Boiling Point	427.2±55.0 °C at 760 mmHg
Flash Point	212.1±31.5 °C
Purity	>98.0%
Density	1.3±0.1 g/cm3
Solubility	10 mm in DMSO
Appearance	Transparent Liquid
Shelf Life	0-4°C for short term (days to weeks), or -20°C for long term (months).
Storage	Store at -20 °C, keep in dry and avoid sunlight.
Vapor Pressure	0.0±1.0 mmHg at 25°C
LogP	-1.96

Propargyl-PEG3-NHS ester, a versatile reagent in biomolecular research and chemical synthesis, boasts a myriad of applications characterized by high perplexity and burstiness.

Bioconjugation: Delving into the realm of bioconjugates, Propargyl-PEG3-NHS ester showcases its prowess through click chemistry, intricately linking biomolecules. By engaging the NHS ester with primary amines on proteins or peptides, intricate conjugates emerge, serving varied functions such as targeted drug delivery and diagnostic assays. This interplay of chemical bonds in biological contexts unravels a tapestry of complex connections.

Surface Functionalization: Scientists harness Propargyl-PEG3-NHS ester for surface functionalization in biosensor development and bio-interface applications. By introducing alkyne groups through this reagent, surfaces are primed for interactions with azide-modified molecules, setting the stage for precise engagements with target molecules like antibodies or enzymes. This labyrinth of material modification opens pathways to intricate bioactive interactions.

Drug Delivery Systems: Transforming drug carriers like liposomes or nanoparticles, Propargyl-PEG3-NHS ester elevates targeting and biocompatibility. The PEG component enhances solubility and diminishes immune responses, while the propargyl group lays the groundwork for further click chemistry derivatization. This intricate modification amplifies the efficacy and specificity of drug delivery systems, exemplifying the complex choreography of functionalization in biomedical progress.

Protein Labeling: In the intricate world of proteomics and biochemical studies, Propargyl-PEG3-NHS ester takes center stage in labeling proteins with fluorophores, biotin, or other tags. By covalently attaching to lysine residues on proteins, this reagent facilitates tracking, isolation, and visualization of labeled proteins in intricate biological samples. This labeling process intricately weaves layers of complexity into analytical and diagnostic applications, shedding light on the elaborate molecular interactions within biological systems.

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