Propargyl-PEG5-amine

Name: Propargyl-PEG5-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-1869
Product Name	Propargyl-PEG5-amine
CAS	1589522-46-2
Molecular Formula	C13H25NO5
Molecular Weight	275.34

Scheme Design
Custom Synthesis
cGMP Manufacturing
Quality Assurance

Product Information
Application
Documents
Reviews

Product Information

Description	Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Synonyms	Propargyl-PEG5-NH2
IUPAC Name	2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine
SMILES	C#CCOCCOCCOCCOCCOCCN
InChI	InChI=1S/C13H25NO5/c1-2-4-15-6-8-17-10-12-19-13-11-18-9-7-16-5-3-14/h1H,3-14H2
InChIKey	BLBTXXAWMPTQOK-UHFFFAOYSA-N
Boiling Point	360.4±37.0 °C at 760 mmHg
Flash Point	166.5±20.2 °C
Purity	>98.0%
Density	1.0±0.1 g/cm3
Solubility	10 mm in DMSO
Appearance	Colorless Liquid
Shelf Life	0-4°C for short term (days to weeks), or -20°C for long term (months).
Storage	Store at -5°C,keep in dry and avoid sunlight.
Vapor Pressure	0.0±0.8 mmHg at 25°C
LogP	-1.54

Propargyl-PEG5-amine, a versatile bifunctional reagent, plays a pivotal role in biochemical research and pharmaceutical development. Here are four key applications of Propargyl-PEG5-amine presented with high perplexity and burstiness:

Bioorthogonal Chemistry: Acting as a cornerstone in bioorthogonal reactions like copper-catalyzed azide-alkyne cycloaddition (CuAAC), Propargyl-PEG5-amine enables the selective conjugation of biomolecules within intricate mixtures, preserving the integrity of native biological processes. This chemistry is indispensable for labeling and tracing biomolecules within the dynamic milieu of live cells and organisms.

Drug Delivery Systems: Embraced in drug formulation, Propargyl-PEG5-amine serves as a linchpin in creating prodrug conjugates and sophisticated drug delivery systems. Through PEGylation, which bolsters solubility, stability, and bioavailability of therapeutic agents, researchers can engineer drug-PEG5-amine conjugates via click chemistry, elevating pharmacokinetics and dampening immunogenicity of medicinal compounds.

Surface Modification: Employed for the surface alteration of nanoparticles, biosensors, and medical devices, Propargyl-PEG5-amine combines the advantages of the PEG moiety for biocompatibility and the alkyne group for further functionalization through click chemistry. This application is instrumental in crafting cutting-edge diagnostic instruments and ensuring the compatibility of implantable medical devices with biological systems.

Proteomics and Glycomics: In the intricate realms of proteomics and glycomics, Propargyl-PEG5-amine stands as a linchpin for targeted tagging of proteins and glycans. By anchoring this reagent to specific functional groups, researchers can meticulously extract and characterize biomolecules from complex samples, offering invaluable insights into protein interactions, glycosylation dynamics, and biomarker discovery.

Documents

SDS
COAs

Reviews

If you have any suggestions or comments about Propargyl-PEG5-amine , please submit a review immediately.

Related Link

Why BOC Sciences?

Large Stock

More than 2000+ products in inventory
Global Delivery

Warehouses in multiple cities to ensure fast delivery
mg to kg

Multi specification for academic research and industrial production
24/7 Technical Support

Strict process parameter control to ensure product quality

Our Feature

BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.