Azido-PEG10-Acid

Name: Azido-PEG10-Acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Azido-PEGn-Acid
Catalog NO.	BPG-0854
Product Name	Azido-PEG10-Acid
CAS	1644163-57-4
Molecular Formula	C23H45N3O12
Molecular Weight	555.62

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Description	Azido-PEG10-Acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms	N3-PEG10-COOH; Azido-PEG10-C2-acid; N3-PEG10-CH2CH2COOH; Propanoic acid, 3-[(29-azido-3,6,9,12,15,18,21,24,27-nonaoxanonacos-1-yl)oxy]-; 1-Azido-3,6,9,12,15,18,21,24,27,30-decaoxatritriacontan-33-oic acid; 3,6,9,12,15,18,21,24,27,30-Decaoxatritriacontan-33-oic acid, 1-azido-
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
SMILES	C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)O
InChI	InChI=1S/C23H45N3O12/c24-26-25-2-4-30-6-8-32-10-12-34-14-16-36-18-20-38-22-21-37-19-17-35-15-13-33-11-9-31-7-5-29-3-1-23(27)28/h1-22H2,(H,27,28)
InChIKey	UOKQXCSLUSWFRF-UHFFFAOYSA-N
Purity	≥95%
Solubility	Soluble in DMF, DMSO, Water
Related CAS	1167575-20-3 (polymer)
Appearance	Pale Yellow Oily Matter
Storage	Store at 2-8°C

Azido-PEG10-Acid, a versatile chemical compound utilized in diverse biomedical and biotechnological contexts, offers boundless opportunities. Here are four key applications of Azido-PEG10-Acid explored through high perplexity and burstiness:

Bioorthogonal Chemistry: At the forefront of bioorthogonal chemistry, Azido-PEG10-Acid emerges as a pivotal tool for labeling and tracing biomolecules within living systems. Its azide group engages in selective reactions with alkyne or cyclooctyne via click chemistry, facilitating precise attachment of probes or drugs to target molecules. This technique enables real-time visualization and analysis of intricate biological processes.

Drug Delivery Systems: In the realm of advanced drug delivery systems, Azido-PEG10-Acid plays a crucial role by leveraging its polyethylene glycol (PEG) component to enhance the solubility and stability of therapeutic agents. Conjugation of drugs to Azido-PEG10-Acid enables targeted delivery to specific tissues or cells, minimizing off-target effects, and enhancing therapeutic efficacy. This approach proves particularly advantageous in precision cancer therapy and other targeted interventions.

Nanotechnology: Within the dynamic field of nanotechnology, Azido-PEG10-Acid serves as a cornerstone for functionalizing nanoparticles in a myriad of biomedical applications. The PEGylation bestowed by Azido-PEG10-Acid diminishes immunogenicity and augments biocompatibility of nanoparticles, extending circulation time and bolstering targeting precision. This enhancement renders nanoparticles ideal for applications spanning imaging, diagnostics, and drug delivery.

Protein Engineering: In the realm of protein engineering, Azido-PEG10-Acid emerges as an indispensable asset for site-specific protein modification. By integrating azide groups into proteins through genetic or chemical means, researchers possess the capability to affix diverse functional groups or probes to specific protein sites. This methodology facilitates in-depth exploration of protein functionality, interactions, and pathways.

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