Azido-PEG8-propionic acid

Name: Azido-PEG8-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

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Category	Azido-PEGn-Acid
Catalog NO.	BPG-2210
Product Name	Azido-PEG8-propionic acid
CAS	1214319-92-2
Molecular Formula	C19H37N3O10
Molecular Weight	467.51

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Description	Azido-PEG8-propionic acid acts as a versatile ADC linker with azide functionality, facilitating bioorthogonal conjugation and improving ADC stability and payload release control.
Synonyms	Azido-PEG8-acid;N3-PEG8-COOH; Azido-PEG8-C2-acid; Azido-PEG8-Acid; N3-PEG8-CH2CH2COOH; 1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid; 3,6,9,12,15,18,21,24-Octaoxaheptacosan-27-oic acid, 1-azido-; Azido-dPEG(R)8-acid
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
SMILES	C(COCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)O
InChI	InChI=1S/C19H37N3O10/c20-22-21-2-4-26-6-8-28-10-12-30-14-16-32-18-17-31-15-13-29-11-9-27-7-5-25-3-1-19(23)24/h1-18H2,(H,23,24)
InChIKey	URUGOEBULOZLBF-UHFFFAOYSA-N
Purity	≥95%
Solubility	Soluble in DCM, DMF, DMSO, Water
Related CAS	1167575-20-3 (polymer)
Appearance	Pale Yellow Oily Matter
Shelf Life	0-4°C for short term (days to weeks), or -20°C for long term (months).
Storage	Store at 2-8°C

Azido-PEG8-propionic acid, a versatile chemical reagent, plays a pivotal role in bioconjugation and biomedical research. Here are four key applications of Azido-PEG8-propionic acid presented with high perplexity and burstiness:

Bioconjugation: A cornerstone of bioconjugation, Azido-PEG8-propionic acid serves as a linchpin in linking biomolecules like proteins, peptides, and antibodies to diverse surfaces or tags. Its azide group engages in precise click chemistry reactions with alkynes, fostering the formation of sturdy covalent bonds. This process facilitates the functionalization of biomolecules, propelling advancements in diagnostics, drug delivery, and biosensor development.

Drug Delivery Systems: Delving into the realm of drug delivery systems, Azido-PEG8-propionic acid emerges as a game-changer, enhancing the delivery and therapeutic efficacy of drug molecules or carriers. The PEG moiety imparts heightened solubility and diminished immunogenicity, while the azido group enables site-specific conjugation. This refined approach augments the precision in targeting and releasing drugs at designated sites within the body, revolutionizing treatment outcomes.

Surface Functionalization: In the intricate field of materials science, Azido-PEG8-propionic acid finds application in the functionalization of surfaces like nanoparticles, hydrogels, and medical devices. This compound is instrumental in attaching bioactive molecules or probes to surfaces via click chemistry, crafting biofunctional interfaces. Such innovations prove invaluable in the development of biosensors, tissue engineering scaffolds, and biocompatible coatings, driving progress in diverse sectors.

Protein Labeling: Azido-PEG8-propionic acid emerges as a key player in protein labeling within proteomics and cell biology landscapes. By integrating this reagent into proteins, researchers can affix fluorescent dyes or other tags, facilitating visualization and tracking of proteins amidst complex biological systems. This application holds profound significance in unraveling protein localization, interactions, and dynamics, offering invaluable insights into cellular processes.

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