SPDP-PEG11-NHS ester
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| Category | SPDP-PEGn-NHS ester |
| Catalog NO. | BPG-3499 |
| Product Name | SPDP-PEG11-NHS ester |
| Molecular Formula | C37H61N3O16S2 |
| Molecular Weight | 868.02 |
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Product Information
| Description | SPDP-PEG11-NHS ester is a PEG-based PROTAC linker that has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. |
| Synonyms | SPDP-dpeg(R)11-NHS ester; Opss-peg(11)-nhs; 2,5-dioxopyrrolidin-1-yl 2-((2-(3-(pyridin-2-yldisulfaneyl)propanamido)ethoxy)methyl)-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontanoate |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| SMILES | O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCSSC2=NC=CC=C2)=O |
| InChI | InChI=1S/C37H61N3O16S2/c41-33(7-32-57-58-34-3-1-2-8-39-34)38-9-11-46-13-15-48-17-19-50-21-23-52-25-27-54-29-31-55-30-28-53-26-24-51-22-20-49-18-16-47-14-12-45-10-6-37(44)56-40-35(42)4-5-36(40)43/h1-3,8H,4-7,9-32H2,(H,38,41) |
| InChIKey | JEHVEPIBCVCTAS-UHFFFAOYSA-N |
| Purity | ≥95% |
| Appearance | Colorless Oily Matter |
| Storage | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
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PEGylation of Peptides
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