SPDP-PEG4-NHS ester
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| Category | SPDP-PEGn-NHS ester |
| Catalog NO. | BPG-3503 |
| Product Name | SPDP-PEG4-NHS ester |
| CAS | 1334177-95-5 |
| Molecular Formula | C23H33N3O9S2 |
| Molecular Weight | 559.65 |
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Product Information
| Description | SPDP-PEG4-NHS ester is a PEG-based PROTAC linker that has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. |
| Synonyms | SPDP-dpeg(R)4-NHS ester; 2,5-Dioxo-1-pyrrolidinyl 17-oxo-19-(2-pyridinyldithio)-4,7,10,13-tetraoxa-16-azanonadecanoate; Opss-peg(4)-nhs; N-[3-(o-Pyridyldisulfido)propanoyl]-15-amino-4,7,10,13-tetraoxa-pentadecanoyl succinimidyl ester; NHS-PEG4-SDPD; 2,5-dioxopyrrolidin-1-yl 3-oxo-1-(pyridin-2-yldisulfanyl)-7,10,13,16-tetraoxa-4-azanonadecan-19-oate |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCNC(=O)CCSSC2=CC=CC=N2 |
| InChI | InChI=1S/C23H33N3O9S2/c27-19(7-18-36-37-20-3-1-2-8-25-20)24-9-11-32-13-15-34-17-16-33-14-12-31-10-6-23(30)35-26-21(28)4-5-22(26)29/h1-3,8H,4-7,9-18H2,(H,24,27) |
| InChIKey | QTVBGVZVUCIFAH-UHFFFAOYSA-N |
| Purity | ≥95% |
| Density | 1.3±0.1 g/cm3 |
| Appearance | Red Solid |
| Storage | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
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