SPDP-PEG12-NHS ester
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| Category | SPDP-PEGn-NHS ester |
| Catalog NO. | BPG-3497 |
| Product Name | SPDP-PEG12-NHS ester |
| CAS | 2601437-72-1 |
| Molecular Formula | C39H65N3O17S2 |
| Molecular Weight | 912.07 |
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Product Information
| Description | SPDP-PEG12-NHS ester is a PEG-based PROTAC linker that has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. |
| Synonyms | SPDP-dPEG(R)12-NHS ester; Opss-peg(12)-nhs; alpha-[3-(o-Pyridyldisulfido)propanoylamido]-omega-succinimidyl ester dodeca(ethylene glycol); 2,5-dioxopyrrolidin-1-yl 2-((2-(3-(pyridin-2-yldisulfaneyl)propanamido)ethoxy)methyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontanoate |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-(pyridin-2-yldisulfanyl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCSSC2=CC=CC=N2 |
| InChI | InChI=1S/C39H65N3O17S2/c43-35(7-34-60-61-36-3-1-2-8-41-36)40-9-11-48-13-15-50-17-19-52-21-23-54-25-27-56-29-31-58-33-32-57-30-28-55-26-24-53-22-20-51-18-16-49-14-12-47-10-6-39(46)59-42-37(44)4-5-38(42)45/h1-3,8H,4-7,9-34H2,(H,40,43) |
| InChIKey | PQUMQQHUIZYDPW-UHFFFAOYSA-N |
| Purity | ≥95% |
| Density | 1.3±0.1 g/cm3 |
| Related CAS | 924280-65-9 |
| Appearance | Colorless Oily Matter |
| Storage | Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years) |
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