Bis-PEG3-NHS Ester
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| Category | Bis-PEGn-NHS ester |
| Catalog NO. | BPG-3568 |
| Product Name | Bis-PEG3-NHS Ester |
| CAS | 1314378-16-9 |
| Molecular Formula | C18H24N2O11 |
| Molecular Weight | 444.39 |
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Product Information
| Description | Bis-PEG3-NHS Ester is used in ADC construction for efficient crosslinking of proteins via primary amines. Its PEG3 spacer enhances solubility, reduces immunogenicity, and enables controlled drug loading on antibodies. |
| Synonyms | α,ω-disuccinimidyl diethylene glycol; bis(2,5-dioxopyrrolidin-1-yl) 3,3'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))dipropanoate; 1,1'-Bis(2,5-dioxo-1-pyrrolidinyl) 3,3'-[oxybis(2,1-ethanediyloxy)]bis[propanoate]; Propanoic acid, 3,3'-[oxybis(2,1-ethanediyloxy)]bis-, 1,1'-bis(2,5-dioxo-1-pyrrolidinyl) ester; 1,1'-{Oxybis[2,1-ethanediyloxy(1-oxo-3,1-propanediyl)oxy]}di(2,5-pyrrolidinedione); 2,5-Pyrrolidinedione, 1,1'-[oxybis[2,1-ethanediyloxy(1-oxo-3,1-propanediyl)oxy]]bis-; NHS-PEG3-NHS |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]propanoate |
| SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCC(=O)ON2C(=O)CCC2=O |
| InChI | InChI=1S/C18H24N2O11/c21-13-1-2-14(22)19(13)30-17(25)5-7-27-9-11-29-12-10-28-8-6-18(26)31-20-15(23)3-4-16(20)24/h1-12H2 |
| InChIKey | OPGNUERFYQLUNP-UHFFFAOYSA-N |
| Boiling Point | 577.4±60.0°C (Predicted) |
| Purity | ≥98% |
| Density | 1.42±0.1 g/cm3 (Predicted) |
| Solubility | Soluble in DMSO |
| Related CAS | 123502-57-8 (polymer) |
| Appearance | Pale Yellow or Colorless Oily Matter |
| Storage | Store at 2-8°C |
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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.
PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS
PEG linkers For Drug
Improved Circulation Half-Life
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